PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Handroanthus impetiginosus
Species TF ID Description
PIM97343.1MIKC_MADS family protein
PIM98502.1MIKC_MADS family protein
PIM98710.1MIKC_MADS family protein
PIM99666.1MIKC_MADS family protein
PIM99980.1MIKC_MADS family protein
PIN00412.1MIKC_MADS family protein
PIN00687.1MIKC_MADS family protein
PIN01001.1MIKC_MADS family protein
PIN01002.1MIKC_MADS family protein
PIN01165.1MIKC_MADS family protein
PIN01410.1MIKC_MADS family protein
PIN01411.1MIKC_MADS family protein
PIN02379.1MIKC_MADS family protein
PIN03147.1MIKC_MADS family protein
PIN03685.1MIKC_MADS family protein
PIN05942.1MIKC_MADS family protein
PIN05943.1MIKC_MADS family protein
PIN06288.1MIKC_MADS family protein
PIN06514.1MIKC_MADS family protein
PIN06533.1MIKC_MADS family protein
PIN06534.1MIKC_MADS family protein
PIN06593.1MIKC_MADS family protein
PIN06594.1MIKC_MADS family protein
PIN07703.1MIKC_MADS family protein
PIN08339.1MIKC_MADS family protein
PIN10214.1MIKC_MADS family protein
PIN10459.1MIKC_MADS family protein
PIN10460.1MIKC_MADS family protein
PIN11426.1MIKC_MADS family protein
PIN11433.1MIKC_MADS family protein
PIN11502.1MIKC_MADS family protein
PIN12501.1MIKC_MADS family protein
PIN12664.1MIKC_MADS family protein
PIN15385.1MIKC_MADS family protein
PIN16067.1MIKC_MADS family protein
PIN16095.1MIKC_MADS family protein
PIN17675.1MIKC_MADS family protein
PIN17677.1MIKC_MADS family protein
PIN20338.1MIKC_MADS family protein
PIN20339.1MIKC_MADS family protein
PIN21348.1MIKC_MADS family protein
PIN21683.1MIKC_MADS family protein
PIN23417.1MIKC_MADS family protein
PIN23648.1MIKC_MADS family protein
PIN26260.1MIKC_MADS family protein
PIN26262.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513