PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Handroanthus impetiginosus
HD-ZIP Family
Species TF ID Description
PIM97397.1HD-ZIP family protein
PIM98915.1HD-ZIP family protein
PIM99402.1HD-ZIP family protein
PIM99537.1HD-ZIP family protein
PIN00165.1HD-ZIP family protein
PIN02124.1HD-ZIP family protein
PIN02334.1HD-ZIP family protein
PIN02703.1HD-ZIP family protein
PIN03003.1HD-ZIP family protein
PIN04076.1HD-ZIP family protein
PIN04145.1HD-ZIP family protein
PIN04592.1HD-ZIP family protein
PIN06045.1HD-ZIP family protein
PIN06274.1HD-ZIP family protein
PIN07333.1HD-ZIP family protein
PIN07384.1HD-ZIP family protein
PIN07815.1HD-ZIP family protein
PIN08794.1HD-ZIP family protein
PIN09155.1HD-ZIP family protein
PIN11128.1HD-ZIP family protein
PIN11335.1HD-ZIP family protein
PIN12105.1HD-ZIP family protein
PIN13338.1HD-ZIP family protein
PIN13685.1HD-ZIP family protein
PIN15052.1HD-ZIP family protein
PIN15218.1HD-ZIP family protein
PIN15591.1HD-ZIP family protein
PIN15729.1HD-ZIP family protein
PIN16269.1HD-ZIP family protein
PIN16422.1HD-ZIP family protein
PIN17024.1HD-ZIP family protein
PIN18690.1HD-ZIP family protein
PIN19438.1HD-ZIP family protein
PIN20681.1HD-ZIP family protein
PIN22001.1HD-ZIP family protein
PIN22422.1HD-ZIP family protein
PIN22932.1HD-ZIP family protein
PIN23476.1HD-ZIP family protein
PIN24501.1HD-ZIP family protein
PIN24611.1HD-ZIP family protein
PIN24958.1HD-ZIP family protein
PIN25179.1HD-ZIP family protein
PIN25554.1HD-ZIP family protein
PIN25984.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401