PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Hevea brasiliensis
ZF-HD Family
Species TF ID Description
XP_021638820.1ZF-HD family protein
XP_021638975.1ZF-HD family protein
XP_021638976.1ZF-HD family protein
XP_021638977.1ZF-HD family protein
XP_021639165.1ZF-HD family protein
XP_021639532.1ZF-HD family protein
XP_021640090.1ZF-HD family protein
XP_021644177.1ZF-HD family protein
XP_021645110.1ZF-HD family protein
XP_021645948.1ZF-HD family protein
XP_021645956.1ZF-HD family protein
XP_021645965.1ZF-HD family protein
XP_021645969.1ZF-HD family protein
XP_021651266.1ZF-HD family protein
XP_021651738.1ZF-HD family protein
XP_021652366.1ZF-HD family protein
XP_021653474.1ZF-HD family protein
XP_021661675.1ZF-HD family protein
XP_021663494.1ZF-HD family protein
XP_021667434.1ZF-HD family protein
XP_021673178.1ZF-HD family protein
XP_021673179.1ZF-HD family protein
XP_021673181.1ZF-HD family protein
XP_021674305.1ZF-HD family protein
XP_021680646.1ZF-HD family protein
XP_021680647.1ZF-HD family protein
XP_021680648.1ZF-HD family protein
XP_021683684.1ZF-HD family protein
XP_021684058.1ZF-HD family protein
XP_021684980.1ZF-HD family protein
XP_021685155.1ZF-HD family protein
XP_021687903.1ZF-HD family protein
XP_021687904.1ZF-HD family protein
XP_021687918.1ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511