PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Ensete ventricosum
M-type_MADS Family
Species TF ID Description
RWV81739.1M-type_MADS family protein
RWV81789.1M-type_MADS family protein
RWV81941.1M-type_MADS family protein
RWV83758.1M-type_MADS family protein
RWV84914.1M-type_MADS family protein
RWV85051.1M-type_MADS family protein
RWV85133.1M-type_MADS family protein
RWV86150.1M-type_MADS family protein
RWV86575.1M-type_MADS family protein
RWV87075.1M-type_MADS family protein
RWV87076.1M-type_MADS family protein
RWV88221.1M-type_MADS family protein
RWV88796.1M-type_MADS family protein
RWV89094.1M-type_MADS family protein
RWV89487.1M-type_MADS family protein
RWV89883.1M-type_MADS family protein
RWV91216.1M-type_MADS family protein
RWV91900.1M-type_MADS family protein
RWV92528.1M-type_MADS family protein
RWV92529.1M-type_MADS family protein
RWV92706.1M-type_MADS family protein
RWV94046.1M-type_MADS family protein
RWV94184.1M-type_MADS family protein
RWV94439.1M-type_MADS family protein
RWV95723.1M-type_MADS family protein
RWV96315.1M-type_MADS family protein
RWV96691.1M-type_MADS family protein
RWV96967.1M-type_MADS family protein
RWV97048.1M-type_MADS family protein
RWV98702.1M-type_MADS family protein
RWW00069.1M-type_MADS family protein
RWW00634.1M-type_MADS family protein
RWW00781.1M-type_MADS family protein
RWW01141.1M-type_MADS family protein
RWW04013.1M-type_MADS family protein
RWW04298.1M-type_MADS family protein
RWW07465.1M-type_MADS family protein
RWW07592.1M-type_MADS family protein
RWW08136.1M-type_MADS family protein
RWW08798.1M-type_MADS family protein
RWW08804.1M-type_MADS family protein
RWW09465.1M-type_MADS family protein
RWW10378.1M-type_MADS family protein
RWW11267.1M-type_MADS family protein
RWW11565.1M-type_MADS family protein
RWW12430.1M-type_MADS family protein
RWW12622.1M-type_MADS family protein
RWW13095.1M-type_MADS family protein
RWW16263.1M-type_MADS family protein
RWW19126.1M-type_MADS family protein
RWW19659.1M-type_MADS family protein
RWW19972.1M-type_MADS family protein
RWW20454.1M-type_MADS family protein
RWW20522.1M-type_MADS family protein
RWW20524.1M-type_MADS family protein
RWW21207.1M-type_MADS family protein
RWW21214.1M-type_MADS family protein
RWW23231.1M-type_MADS family protein
RWW26756.1M-type_MADS family protein
RWW26811.1M-type_MADS family protein
RWW28802.1M-type_MADS family protein
RWW29000.1M-type_MADS family protein
RWW29133.1M-type_MADS family protein
RWW29480.1M-type_MADS family protein
RWW29905.1M-type_MADS family protein
RWW30655.1M-type_MADS family protein
RWW31173.1M-type_MADS family protein
RWW31690.1M-type_MADS family protein
RWW32523.1M-type_MADS family protein
RWW32861.1M-type_MADS family protein
RWW32957.1M-type_MADS family protein
RWW33302.1M-type_MADS family protein
RWW33777.1M-type_MADS family protein
RWW34204.1M-type_MADS family protein
RWW34370.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513