PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Dendrobium catenatum
ZF-HD Family
Species TF ID Description
XP_020678177.1ZF-HD family protein
XP_020678820.1ZF-HD family protein
XP_020679046.1ZF-HD family protein
XP_020679682.2ZF-HD family protein
XP_020680650.1ZF-HD family protein
XP_020680706.1ZF-HD family protein
XP_020681166.1ZF-HD family protein
XP_020681238.1ZF-HD family protein
XP_020686975.1ZF-HD family protein
XP_020687171.1ZF-HD family protein
XP_020693549.1ZF-HD family protein
XP_020693554.1ZF-HD family protein
XP_020693559.1ZF-HD family protein
XP_020693580.1ZF-HD family protein
XP_020693597.1ZF-HD family protein
XP_020693963.1ZF-HD family protein
XP_020696897.1ZF-HD family protein
XP_020697661.1ZF-HD family protein
XP_020697748.1ZF-HD family protein
XP_020701157.1ZF-HD family protein
XP_020702221.1ZF-HD family protein
XP_020704280.1ZF-HD family protein
XP_028553903.1ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511