PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Camellia sinensis var. sinensis
SBP Family
Species TF ID Description
XP_028053667.1SBP family protein
XP_028054458.1SBP family protein
XP_028059188.1SBP family protein
XP_028067996.1SBP family protein
XP_028071909.1SBP family protein
XP_028071910.1SBP family protein
XP_028071911.1SBP family protein
XP_028071912.1SBP family protein
XP_028071913.1SBP family protein
XP_028074804.1SBP family protein
XP_028076084.1SBP family protein
XP_028076085.1SBP family protein
XP_028076086.1SBP family protein
XP_028077063.1SBP family protein
XP_028077116.1SBP family protein
XP_028078083.1SBP family protein
XP_028078297.1SBP family protein
XP_028092785.1SBP family protein
XP_028092786.1SBP family protein
XP_028092787.1SBP family protein
XP_028092788.1SBP family protein
XP_028092789.1SBP family protein
XP_028093786.1SBP family protein
XP_028093787.1SBP family protein
XP_028093788.1SBP family protein
XP_028093795.1SBP family protein
XP_028093800.1SBP family protein
XP_028094733.1SBP family protein
XP_028094734.1SBP family protein
XP_028098790.1SBP family protein
XP_028098791.1SBP family protein
XP_028098792.1SBP family protein
XP_028107208.1SBP family protein
XP_028107377.1SBP family protein
XP_028107378.1SBP family protein
XP_028107379.1SBP family protein
XP_028107380.1SBP family protein
XP_028110050.1SBP family protein
XP_028110429.1SBP family protein
XP_028110481.1SBP family protein
XP_028110698.1SBP family protein
XP_028110768.1SBP family protein
XP_028112290.1SBP family protein
XP_028112291.1SBP family protein
XP_028114704.1SBP family protein
XP_028114705.1SBP family protein
XP_028114706.1SBP family protein
XP_028114707.1SBP family protein
XP_028114708.1SBP family protein
XP_028114710.1SBP family protein
XP_028124934.1SBP family protein
XP_028124935.1SBP family protein
XP_028124936.1SBP family protein
XP_028124937.1SBP family protein
XP_028125244.1SBP family protein
SBP Family Introduction

SQUAMOSA promoter binding proteins (SBPs) form a major family of plant-specific transcription factors related to flower development. Although SBPs are heterogeneous in primary structure, they share a highly conserved DNA-binding domain (DBD) that has been suggested to be zinc binding. Here we report the NMR solution structures of DBDs of two SBPs of Arabidopsis thaliana, SPL4 and SPL7. The two share essentially the same structural features. Each structure contains two zinc-binding sites consisting of eight Cys or His residues in a Cys3HisCys2HisCys or Cys6HisCys sequence motif in which the first four residues coordinate to one zinc and the last four coordinate to the other. These structures are dissimilar to other known zinc-binding structures, and thus represent a novel type of zinc-binding motif. The electrostatic profile on the surface suggested that a continuous region, including all the conserved basic residues, is involved in the DNA binding, the mode of which is likely to be novel as well.

Yamasaki K, Kigawa T, Inoue M, Tateno M, Yamasaki T, Yabuki T, Aoki M, Seki E, Matsuda T, Nunokawa E, Ishizuka Y, Terada T, Shirouzu M, Osanai T, Tanaka A, Seki M, Shinozaki K, Yokoyama S.
A novel zinc-binding motif revealed by solution structures of DNA-binding domains of Arabidopsis SBP-family transcription factors
J Mol Biol. 2004 Mar 12;337(1):49-63.
PMID: 15001351

SBP-box genes were first characterized as SQUAMOSA promoter binding proteins (SBPs) to regulate the expression of MADS-box genes in early flower development of A. majus (Klein et al., 1996). Since then, SBP-box genes have been identified in many plants including green alga, moss, silver birch, A. majus, Arabidopsis and maize. They play critical roles in regulating flower and fruit development as well as other physiological processes ([Moreno et al., 1997],[Eriksson et al., 2004], [Lannenpaa et al., 2004], [Arazi et al., 2005] and [Kropat et al., 2005]). It has been reported that Arabidopsis SPL3, SPL8 and SPL14 involves in flowering, sporogenesis, GA signaling and toxin resistance ([Cardon et al., 1997], [Unte et al., 2003], [Stone et al., 2005] and [Zhang et al., 2006]) while maize tga1 and tomato LeSPL-CNR affect fruit development ([Wang et al., 2005a] and [Manning et al., 2006]).

SBP-box genes encode proteins sharing a conserved DNA-binding domain of 79 amino acid residues. It has been proved that the DNA-binding domain of SBP-box genes is necessary and sufficient to bind to a palindromic GTAC core motif ([Klein et al., 1996], [Cardon et al., 1997], [Cardon et al., 1999], [Lannenpaa et al., 2004] and [Birkenbihl et al., 2005]). Studies on the NMR solution structure of the fragment of Arabidopsis SPL4 and SPL7 revealed that the DNA-binding domain of SBPs consisted of two separate zinc-binding sites. One zinc finger is C3H or C4 and the other is C2HC (Yamasaki et al., 2004 K. Yamasaki et al.,).

Guo AY, Zhu QH, Gu X, Ge S, Yang J, Luo J.
Genome-wide identification and evolutionary analysis of the plant specific SBP-box transcription factor family.
Gene. 2008 Jul 15;418(1-2):1-8.
PMID: 18495384