PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Camellia sinensis var. sinensis
MIKC_MADS Family
Species TF ID Description
XP_028051247.1MIKC_MADS family protein
XP_028051811.1MIKC_MADS family protein
XP_028052104.1MIKC_MADS family protein
XP_028052192.1MIKC_MADS family protein
XP_028056207.1MIKC_MADS family protein
XP_028058458.1MIKC_MADS family protein
XP_028059192.1MIKC_MADS family protein
XP_028059193.1MIKC_MADS family protein
XP_028059218.1MIKC_MADS family protein
XP_028059352.1MIKC_MADS family protein
XP_028059353.1MIKC_MADS family protein
XP_028060316.1MIKC_MADS family protein
XP_028060317.1MIKC_MADS family protein
XP_028061042.1MIKC_MADS family protein
XP_028061355.1MIKC_MADS family protein
XP_028062146.1MIKC_MADS family protein
XP_028062219.1MIKC_MADS family protein
XP_028062220.1MIKC_MADS family protein
XP_028064640.1MIKC_MADS family protein
XP_028064641.1MIKC_MADS family protein
XP_028065159.1MIKC_MADS family protein
XP_028065160.1MIKC_MADS family protein
XP_028065683.1MIKC_MADS family protein
XP_028065694.1MIKC_MADS family protein
XP_028065702.1MIKC_MADS family protein
XP_028068299.1MIKC_MADS family protein
XP_028068617.1MIKC_MADS family protein
XP_028068618.1MIKC_MADS family protein
XP_028068619.1MIKC_MADS family protein
XP_028068620.1MIKC_MADS family protein
XP_028068621.1MIKC_MADS family protein
XP_028068622.1MIKC_MADS family protein
XP_028068623.1MIKC_MADS family protein
XP_028068624.1MIKC_MADS family protein
XP_028068625.1MIKC_MADS family protein
XP_028068626.1MIKC_MADS family protein
XP_028068984.1MIKC_MADS family protein
XP_028068985.1MIKC_MADS family protein
XP_028068986.1MIKC_MADS family protein
XP_028072706.1MIKC_MADS family protein
XP_028072708.1MIKC_MADS family protein
XP_028072709.1MIKC_MADS family protein
XP_028074828.1MIKC_MADS family protein
XP_028074829.1MIKC_MADS family protein
XP_028074830.1MIKC_MADS family protein
XP_028075263.1MIKC_MADS family protein
XP_028075264.1MIKC_MADS family protein
XP_028075265.1MIKC_MADS family protein
XP_028075266.1MIKC_MADS family protein
XP_028076077.1MIKC_MADS family protein
XP_028076078.1MIKC_MADS family protein
XP_028076079.1MIKC_MADS family protein
XP_028076080.1MIKC_MADS family protein
XP_028076081.1MIKC_MADS family protein
XP_028076082.1MIKC_MADS family protein
XP_028076083.1MIKC_MADS family protein
XP_028078337.1MIKC_MADS family protein
XP_028078338.1MIKC_MADS family protein
XP_028083082.1MIKC_MADS family protein
XP_028083083.1MIKC_MADS family protein
XP_028083085.1MIKC_MADS family protein
XP_028087325.1MIKC_MADS family protein
XP_028087326.1MIKC_MADS family protein
XP_028087327.1MIKC_MADS family protein
XP_028087328.1MIKC_MADS family protein
XP_028093088.1MIKC_MADS family protein
XP_028093089.1MIKC_MADS family protein
XP_028093090.1MIKC_MADS family protein
XP_028093658.1MIKC_MADS family protein
XP_028093665.1MIKC_MADS family protein
XP_028096986.1MIKC_MADS family protein
XP_028100291.1MIKC_MADS family protein
XP_028100773.1MIKC_MADS family protein
XP_028100903.1MIKC_MADS family protein
XP_028100904.1MIKC_MADS family protein
XP_028105061.1MIKC_MADS family protein
XP_028105062.1MIKC_MADS family protein
XP_028105063.1MIKC_MADS family protein
XP_028105064.1MIKC_MADS family protein
XP_028105065.1MIKC_MADS family protein
XP_028106960.1MIKC_MADS family protein
XP_028107381.1MIKC_MADS family protein
XP_028109955.1MIKC_MADS family protein
XP_028109956.1MIKC_MADS family protein
XP_028109957.1MIKC_MADS family protein
XP_028109958.1MIKC_MADS family protein
XP_028111928.1MIKC_MADS family protein
XP_028111929.1MIKC_MADS family protein
XP_028114428.1MIKC_MADS family protein
XP_028117320.1MIKC_MADS family protein
XP_028117321.1MIKC_MADS family protein
XP_028117322.1MIKC_MADS family protein
XP_028117323.1MIKC_MADS family protein
XP_028117324.1MIKC_MADS family protein
XP_028117325.1MIKC_MADS family protein
XP_028117326.1MIKC_MADS family protein
XP_028117348.1MIKC_MADS family protein
XP_028117349.1MIKC_MADS family protein
XP_028119527.1MIKC_MADS family protein
XP_028120350.1MIKC_MADS family protein
XP_028120878.1MIKC_MADS family protein
XP_028125224.1MIKC_MADS family protein
XP_028126894.1MIKC_MADS family protein
XP_028126895.1MIKC_MADS family protein
XP_028126901.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513