PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Chrysanthemum seticuspe
HD-ZIP Family
Species TF ID Description
Cse_sc000371.1_g080.1HD-ZIP family protein
Cse_sc000734.1_g090.1HD-ZIP family protein
Cse_sc001808.1_g040.1HD-ZIP family protein
Cse_sc001911.1_g090.1HD-ZIP family protein
Cse_sc002402.1_g010.1HD-ZIP family protein
Cse_sc002654.1_g020.1HD-ZIP family protein
Cse_sc003783.1_g030.1HD-ZIP family protein
Cse_sc005071.1_g020.1HD-ZIP family protein
Cse_sc005803.1_g050.1HD-ZIP family protein
Cse_sc006617.1_g040.1HD-ZIP family protein
Cse_sc006695.1_g020.1HD-ZIP family protein
Cse_sc007028.1_g010.1HD-ZIP family protein
Cse_sc008209.1_g020.1HD-ZIP family protein
Cse_sc008379.1_g080.1HD-ZIP family protein
Cse_sc008426.1_g010.1HD-ZIP family protein
Cse_sc008857.1_g030.1HD-ZIP family protein
Cse_sc009033.1_g020.1HD-ZIP family protein
Cse_sc009449.1_g020.1HD-ZIP family protein
Cse_sc009694.1_g030.1HD-ZIP family protein
Cse_sc009940.1_g030.1HD-ZIP family protein
Cse_sc012286.1_g050.1HD-ZIP family protein
Cse_sc012380.1_g020.1HD-ZIP family protein
Cse_sc012576.1_g010.1HD-ZIP family protein
Cse_sc012755.1_g010.1HD-ZIP family protein
Cse_sc013616.1_g020.1HD-ZIP family protein
Cse_sc014205.1_g010.1HD-ZIP family protein
Cse_sc014659.1_g020.1HD-ZIP family protein
Cse_sc015132.1_g010.1HD-ZIP family protein
Cse_sc015273.1_g010.1HD-ZIP family protein
Cse_sc015860.1_g020.1HD-ZIP family protein
Cse_sc017333.1_g030.1HD-ZIP family protein
Cse_sc017628.1_g010.1HD-ZIP family protein
Cse_sc020529.1_g060.1HD-ZIP family protein
Cse_sc022146.1_g020.1HD-ZIP family protein
Cse_sc023018.1_g010.1HD-ZIP family protein
Cse_sc024198.1_g010.1HD-ZIP family protein
Cse_sc024686.1_g020.1HD-ZIP family protein
Cse_sc024791.1_g030.1HD-ZIP family protein
Cse_sc030208.1_g010.1HD-ZIP family protein
Cse_sc035017.1_g010.1HD-ZIP family protein
Cse_sc036635.1_g030.1HD-ZIP family protein
Cse_sc047376.1_g020.1HD-ZIP family protein
Cse_sc048409.1_g030.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401