PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cucurbita pepo subsp. pepo
NF-YA Family
Species TF ID Description
XP_023512693.1NF-YA family protein
XP_023512694.1NF-YA family protein
XP_023512695.1NF-YA family protein
XP_023515220.1NF-YA family protein
XP_023515221.1NF-YA family protein
XP_023516542.1NF-YA family protein
XP_023516543.1NF-YA family protein
XP_023518238.1NF-YA family protein
XP_023518239.1NF-YA family protein
XP_023527628.1NF-YA family protein
XP_023527629.1NF-YA family protein
XP_023530428.1NF-YA family protein
XP_023530429.1NF-YA family protein
XP_023533872.1NF-YA family protein
XP_023533873.1NF-YA family protein
XP_023537393.1NF-YA family protein
XP_023537394.1NF-YA family protein
XP_023537395.1NF-YA family protein
XP_023537396.1NF-YA family protein
XP_023539687.1NF-YA family protein
XP_023543592.1NF-YA family protein
XP_023544362.1NF-YA family protein
XP_023544363.1NF-YA family protein
XP_023546978.1NF-YA family protein
XP_023546979.1NF-YA family protein
XP_023547824.1NF-YA family protein
XP_023547825.1NF-YA family protein
XP_023547826.1NF-YA family protein
XP_023547827.1NF-YA family protein
XP_023552348.1NF-YA family protein
XP_023552349.1NF-YA family protein
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982