PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cucurbita pepo subsp. pepo
Species TF ID Description
XP_023511719.1MIKC_MADS family protein
XP_023512279.1MIKC_MADS family protein
XP_023514206.1MIKC_MADS family protein
XP_023514717.1MIKC_MADS family protein
XP_023514991.1MIKC_MADS family protein
XP_023514992.1MIKC_MADS family protein
XP_023515185.1MIKC_MADS family protein
XP_023515187.1MIKC_MADS family protein
XP_023517620.1MIKC_MADS family protein
XP_023518205.1MIKC_MADS family protein
XP_023518206.1MIKC_MADS family protein
XP_023518267.1MIKC_MADS family protein
XP_023518268.1MIKC_MADS family protein
XP_023518529.1MIKC_MADS family protein
XP_023519051.1MIKC_MADS family protein
XP_023519255.1MIKC_MADS family protein
XP_023519986.1MIKC_MADS family protein
XP_023523554.1MIKC_MADS family protein
XP_023523555.1MIKC_MADS family protein
XP_023523556.1MIKC_MADS family protein
XP_023523558.1MIKC_MADS family protein
XP_023523559.1MIKC_MADS family protein
XP_023523560.1MIKC_MADS family protein
XP_023523689.1MIKC_MADS family protein
XP_023523891.1MIKC_MADS family protein
XP_023525011.1MIKC_MADS family protein
XP_023525012.1MIKC_MADS family protein
XP_023525013.1MIKC_MADS family protein
XP_023525014.1MIKC_MADS family protein
XP_023525356.1MIKC_MADS family protein
XP_023525463.1MIKC_MADS family protein
XP_023525464.1MIKC_MADS family protein
XP_023525961.1MIKC_MADS family protein
XP_023526590.1MIKC_MADS family protein
XP_023526608.1MIKC_MADS family protein
XP_023527244.1MIKC_MADS family protein
XP_023527245.1MIKC_MADS family protein
XP_023532454.1MIKC_MADS family protein
XP_023532455.1MIKC_MADS family protein
XP_023533585.1MIKC_MADS family protein
XP_023533586.1MIKC_MADS family protein
XP_023534800.1MIKC_MADS family protein
XP_023536067.1MIKC_MADS family protein
XP_023536068.1MIKC_MADS family protein
XP_023536122.1MIKC_MADS family protein
XP_023536339.1MIKC_MADS family protein
XP_023536340.1MIKC_MADS family protein
XP_023536341.1MIKC_MADS family protein
XP_023537553.1MIKC_MADS family protein
XP_023537829.1MIKC_MADS family protein
XP_023537830.1MIKC_MADS family protein
XP_023537832.1MIKC_MADS family protein
XP_023537833.1MIKC_MADS family protein
XP_023538103.1MIKC_MADS family protein
XP_023538735.1MIKC_MADS family protein
XP_023538736.1MIKC_MADS family protein
XP_023538737.1MIKC_MADS family protein
XP_023542082.1MIKC_MADS family protein
XP_023542083.1MIKC_MADS family protein
XP_023542775.1MIKC_MADS family protein
XP_023543012.1MIKC_MADS family protein
XP_023543013.1MIKC_MADS family protein
XP_023543014.1MIKC_MADS family protein
XP_023543258.1MIKC_MADS family protein
XP_023543261.1MIKC_MADS family protein
XP_023544246.1MIKC_MADS family protein
XP_023544268.1MIKC_MADS family protein
XP_023544269.1MIKC_MADS family protein
XP_023544270.1MIKC_MADS family protein
XP_023544271.1MIKC_MADS family protein
XP_023544399.1MIKC_MADS family protein
XP_023544400.1MIKC_MADS family protein
XP_023544890.1MIKC_MADS family protein
XP_023547090.1MIKC_MADS family protein
XP_023548151.1MIKC_MADS family protein
XP_023549807.1MIKC_MADS family protein
XP_023549984.1MIKC_MADS family protein
XP_023549985.1MIKC_MADS family protein
XP_023549986.1MIKC_MADS family protein
XP_023549987.1MIKC_MADS family protein
XP_023549988.1MIKC_MADS family protein
XP_023552055.1MIKC_MADS family protein
XP_023552056.1MIKC_MADS family protein
XP_023552057.1MIKC_MADS family protein
XP_023552277.1MIKC_MADS family protein
XP_023552278.1MIKC_MADS family protein
XP_023552279.1MIKC_MADS family protein
XP_023552280.1MIKC_MADS family protein
XP_023552281.1MIKC_MADS family protein
XP_023552283.1MIKC_MADS family protein
XP_023552885.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513