PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Cucurbita maxima
MIKC_MADS Family
Species TF ID Description
XP_022966455.1MIKC_MADS family protein
XP_022967891.1MIKC_MADS family protein
XP_022969948.1MIKC_MADS family protein
XP_022970180.1MIKC_MADS family protein
XP_022970181.1MIKC_MADS family protein
XP_022970182.1MIKC_MADS family protein
XP_022970183.1MIKC_MADS family protein
XP_022971943.1MIKC_MADS family protein
XP_022971944.1MIKC_MADS family protein
XP_022971946.1MIKC_MADS family protein
XP_022973440.1MIKC_MADS family protein
XP_022973441.1MIKC_MADS family protein
XP_022973991.1MIKC_MADS family protein
XP_022974114.1MIKC_MADS family protein
XP_022974115.1MIKC_MADS family protein
XP_022974116.1MIKC_MADS family protein
XP_022974117.1MIKC_MADS family protein
XP_022974786.1MIKC_MADS family protein
XP_022975993.1MIKC_MADS family protein
XP_022975994.1MIKC_MADS family protein
XP_022975995.1MIKC_MADS family protein
XP_022975997.1MIKC_MADS family protein
XP_022976853.1MIKC_MADS family protein
XP_022976854.1MIKC_MADS family protein
XP_022977969.1MIKC_MADS family protein
XP_022977970.1MIKC_MADS family protein
XP_022978760.1MIKC_MADS family protein
XP_022978822.1MIKC_MADS family protein
XP_022978823.1MIKC_MADS family protein
XP_022978824.1MIKC_MADS family protein
XP_022979143.1MIKC_MADS family protein
XP_022979144.1MIKC_MADS family protein
XP_022979145.1MIKC_MADS family protein
XP_022980407.1MIKC_MADS family protein
XP_022980707.1MIKC_MADS family protein
XP_022980708.1MIKC_MADS family protein
XP_022980709.1MIKC_MADS family protein
XP_022981045.1MIKC_MADS family protein
XP_022981046.1MIKC_MADS family protein
XP_022981047.1MIKC_MADS family protein
XP_022981049.1MIKC_MADS family protein
XP_022981054.1MIKC_MADS family protein
XP_022981265.1MIKC_MADS family protein
XP_022984237.1MIKC_MADS family protein
XP_022984238.1MIKC_MADS family protein
XP_022984239.1MIKC_MADS family protein
XP_022984682.1MIKC_MADS family protein
XP_022984683.1MIKC_MADS family protein
XP_022984684.1MIKC_MADS family protein
XP_022984685.1MIKC_MADS family protein
XP_022984686.1MIKC_MADS family protein
XP_022984688.1MIKC_MADS family protein
XP_022985132.1MIKC_MADS family protein
XP_022991134.1MIKC_MADS family protein
XP_022991198.1MIKC_MADS family protein
XP_022991247.1MIKC_MADS family protein
XP_022991329.1MIKC_MADS family protein
XP_022991357.1MIKC_MADS family protein
XP_022994147.1MIKC_MADS family protein
XP_022994148.1MIKC_MADS family protein
XP_022994475.1MIKC_MADS family protein
XP_022994528.1MIKC_MADS family protein
XP_022994529.1MIKC_MADS family protein
XP_022994530.1MIKC_MADS family protein
XP_022994531.1MIKC_MADS family protein
XP_022995310.1MIKC_MADS family protein
XP_022995703.1MIKC_MADS family protein
XP_022995704.1MIKC_MADS family protein
XP_022995705.1MIKC_MADS family protein
XP_022998480.1MIKC_MADS family protein
XP_022998481.1MIKC_MADS family protein
XP_022998482.1MIKC_MADS family protein
XP_022998483.1MIKC_MADS family protein
XP_022998484.1MIKC_MADS family protein
XP_022998485.1MIKC_MADS family protein
XP_022998763.1MIKC_MADS family protein
XP_022998764.1MIKC_MADS family protein
XP_022999841.1MIKC_MADS family protein
XP_022999842.1MIKC_MADS family protein
XP_022999843.1MIKC_MADS family protein
XP_023001170.1MIKC_MADS family protein
XP_023001194.1MIKC_MADS family protein
XP_023001459.1MIKC_MADS family protein
XP_023001875.1MIKC_MADS family protein
XP_023001876.1MIKC_MADS family protein
XP_023002153.1MIKC_MADS family protein
XP_023002154.1MIKC_MADS family protein
XP_023003146.1MIKC_MADS family protein
XP_023003147.1MIKC_MADS family protein
XP_023003623.1MIKC_MADS family protein
XP_023003624.1MIKC_MADS family protein
XP_023003989.1MIKC_MADS family protein
XP_023004223.1MIKC_MADS family protein
XP_023004224.1MIKC_MADS family protein
XP_023004227.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513