PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cucurbita maxima
HD-ZIP Family
Species TF ID Description
XP_022965141.1HD-ZIP family protein
XP_022967184.1HD-ZIP family protein
XP_022967185.1HD-ZIP family protein
XP_022968264.1HD-ZIP family protein
XP_022968305.1HD-ZIP family protein
XP_022968413.1HD-ZIP family protein
XP_022968414.1HD-ZIP family protein
XP_022968990.1HD-ZIP family protein
XP_022969629.1HD-ZIP family protein
XP_022970950.1HD-ZIP family protein
XP_022970951.1HD-ZIP family protein
XP_022971346.1HD-ZIP family protein
XP_022972608.1HD-ZIP family protein
XP_022974843.1HD-ZIP family protein
XP_022974844.1HD-ZIP family protein
XP_022975307.1HD-ZIP family protein
XP_022976315.1HD-ZIP family protein
XP_022976582.1HD-ZIP family protein
XP_022977087.1HD-ZIP family protein
XP_022977266.1HD-ZIP family protein
XP_022977681.1HD-ZIP family protein
XP_022977682.1HD-ZIP family protein
XP_022978372.1HD-ZIP family protein
XP_022978526.1HD-ZIP family protein
XP_022978528.1HD-ZIP family protein
XP_022978555.1HD-ZIP family protein
XP_022978812.1HD-ZIP family protein
XP_022979090.1HD-ZIP family protein
XP_022979290.1HD-ZIP family protein
XP_022979311.1HD-ZIP family protein
XP_022979533.1HD-ZIP family protein
XP_022980231.1HD-ZIP family protein
XP_022980232.1HD-ZIP family protein
XP_022980233.1HD-ZIP family protein
XP_022980234.1HD-ZIP family protein
XP_022980940.1HD-ZIP family protein
XP_022982007.1HD-ZIP family protein
XP_022982417.1HD-ZIP family protein
XP_022982418.1HD-ZIP family protein
XP_022982559.1HD-ZIP family protein
XP_022982706.1HD-ZIP family protein
XP_022983019.1HD-ZIP family protein
XP_022983084.1HD-ZIP family protein
XP_022983085.1HD-ZIP family protein
XP_022984098.1HD-ZIP family protein
XP_022984099.1HD-ZIP family protein
XP_022984100.1HD-ZIP family protein
XP_022984101.1HD-ZIP family protein
XP_022984102.1HD-ZIP family protein
XP_022984103.1HD-ZIP family protein
XP_022984558.1HD-ZIP family protein
XP_022984559.1HD-ZIP family protein
XP_022984643.1HD-ZIP family protein
XP_022984644.1HD-ZIP family protein
XP_022984645.1HD-ZIP family protein
XP_022984931.1HD-ZIP family protein
XP_022984932.1HD-ZIP family protein
XP_022985614.1HD-ZIP family protein
XP_022985615.1HD-ZIP family protein
XP_022986268.1HD-ZIP family protein
XP_022986269.1HD-ZIP family protein
XP_022986270.1HD-ZIP family protein
XP_022987342.1HD-ZIP family protein
XP_022987343.1HD-ZIP family protein
XP_022987344.1HD-ZIP family protein
XP_022988693.1HD-ZIP family protein
XP_022989548.1HD-ZIP family protein
XP_022989549.1HD-ZIP family protein
XP_022989986.1HD-ZIP family protein
XP_022989987.1HD-ZIP family protein
XP_022991191.1HD-ZIP family protein
XP_022991918.1HD-ZIP family protein
XP_022992111.1HD-ZIP family protein
XP_022993293.1HD-ZIP family protein
XP_022993652.1HD-ZIP family protein
XP_022993660.1HD-ZIP family protein
XP_022994649.1HD-ZIP family protein
XP_022994650.1HD-ZIP family protein
XP_022995706.1HD-ZIP family protein
XP_022996123.1HD-ZIP family protein
XP_022998050.1HD-ZIP family protein
XP_022998494.1HD-ZIP family protein
XP_022998610.1HD-ZIP family protein
XP_022998611.1HD-ZIP family protein
XP_022999761.1HD-ZIP family protein
XP_022999792.1HD-ZIP family protein
XP_022999814.1HD-ZIP family protein
XP_023000011.1HD-ZIP family protein
XP_023000313.1HD-ZIP family protein
XP_023000314.1HD-ZIP family protein
XP_023000315.1HD-ZIP family protein
XP_023000325.1HD-ZIP family protein
XP_023000326.1HD-ZIP family protein
XP_023000911.1HD-ZIP family protein
XP_023000912.1HD-ZIP family protein
XP_023000993.1HD-ZIP family protein
XP_023001016.1HD-ZIP family protein
XP_023001017.1HD-ZIP family protein
XP_023001018.1HD-ZIP family protein
XP_023001145.1HD-ZIP family protein
XP_023001231.1HD-ZIP family protein
XP_023002930.1HD-ZIP family protein
XP_023003086.1HD-ZIP family protein
XP_023003193.1HD-ZIP family protein
XP_023003346.1HD-ZIP family protein
XP_023003674.1HD-ZIP family protein
XP_023004600.1HD-ZIP family protein
XP_023005508.1HD-ZIP family protein
XP_023005743.1HD-ZIP family protein
XP_023006597.1HD-ZIP family protein
XP_023006686.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401