PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cynara cardunculus var. scolymus
HD-ZIP Family
Species TF ID Description
XP_024961349.1HD-ZIP family protein
XP_024962572.1HD-ZIP family protein
XP_024965686.1HD-ZIP family protein
XP_024966239.1HD-ZIP family protein
XP_024969953.1HD-ZIP family protein
XP_024969954.1HD-ZIP family protein
XP_024969955.1HD-ZIP family protein
XP_024970773.1HD-ZIP family protein
XP_024970780.1HD-ZIP family protein
XP_024971123.1HD-ZIP family protein
XP_024971124.1HD-ZIP family protein
XP_024971444.1HD-ZIP family protein
XP_024971452.1HD-ZIP family protein
XP_024971803.1HD-ZIP family protein
XP_024972195.1HD-ZIP family protein
XP_024972196.1HD-ZIP family protein
XP_024973420.1HD-ZIP family protein
XP_024973890.1HD-ZIP family protein
XP_024973891.1HD-ZIP family protein
XP_024973930.1HD-ZIP family protein
XP_024974470.1HD-ZIP family protein
XP_024975343.1HD-ZIP family protein
XP_024975344.1HD-ZIP family protein
XP_024975497.1HD-ZIP family protein
XP_024976249.1HD-ZIP family protein
XP_024978053.1HD-ZIP family protein
XP_024978055.1HD-ZIP family protein
XP_024978135.1HD-ZIP family protein
XP_024978136.1HD-ZIP family protein
XP_024978595.1HD-ZIP family protein
XP_024979110.1HD-ZIP family protein
XP_024979339.1HD-ZIP family protein
XP_024979340.1HD-ZIP family protein
XP_024979341.1HD-ZIP family protein
XP_024979342.1HD-ZIP family protein
XP_024982070.1HD-ZIP family protein
XP_024983674.1HD-ZIP family protein
XP_024983675.1HD-ZIP family protein
XP_024983676.1HD-ZIP family protein
XP_024984347.1HD-ZIP family protein
XP_024984815.1HD-ZIP family protein
XP_024985513.1HD-ZIP family protein
XP_024985647.1HD-ZIP family protein
XP_024987816.1HD-ZIP family protein
XP_024987842.1HD-ZIP family protein
XP_024988375.1HD-ZIP family protein
XP_024988632.1HD-ZIP family protein
XP_024988633.1HD-ZIP family protein
XP_024988634.1HD-ZIP family protein
XP_024988635.1HD-ZIP family protein
XP_024988636.1HD-ZIP family protein
XP_024988638.1HD-ZIP family protein
XP_024988680.1HD-ZIP family protein
XP_024989714.1HD-ZIP family protein
XP_024989722.1HD-ZIP family protein
XP_024991168.1HD-ZIP family protein
XP_024991925.1HD-ZIP family protein
XP_024992062.1HD-ZIP family protein
XP_024992515.1HD-ZIP family protein
XP_024993578.1HD-ZIP family protein
XP_024993617.1HD-ZIP family protein
XP_024993626.1HD-ZIP family protein
XP_024994043.1HD-ZIP family protein
XP_024994044.1HD-ZIP family protein
XP_024994522.1HD-ZIP family protein
XP_024995523.1HD-ZIP family protein
XP_024996765.1HD-ZIP family protein
XP_024996963.1HD-ZIP family protein
XP_024996964.1HD-ZIP family protein
XP_024996983.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401