PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Capsicum chinense
HD-ZIP Family
Species TF ID Description
PHT99161.1HD-ZIP family protein
PHU00029.1HD-ZIP family protein
PHU00880.1HD-ZIP family protein
PHU01863.1HD-ZIP family protein
PHU02579.1HD-ZIP family protein
PHU02621.1HD-ZIP family protein
PHU03868.1HD-ZIP family protein
PHU04151.1HD-ZIP family protein
PHU04447.1HD-ZIP family protein
PHU05785.1HD-ZIP family protein
PHU06346.1HD-ZIP family protein
PHU07766.1HD-ZIP family protein
PHU09761.1HD-ZIP family protein
PHU12308.1HD-ZIP family protein
PHU15589.1HD-ZIP family protein
PHU17679.1HD-ZIP family protein
PHU19196.1HD-ZIP family protein
PHU19413.1HD-ZIP family protein
PHU20351.1HD-ZIP family protein
PHU20606.1HD-ZIP family protein
PHU23006.1HD-ZIP family protein
PHU23545.1HD-ZIP family protein
PHU23831.1HD-ZIP family protein
PHU24358.1HD-ZIP family protein
PHU24385.1HD-ZIP family protein
PHU25032.1HD-ZIP family protein
PHU25310.1HD-ZIP family protein
PHU25508.1HD-ZIP family protein
PHU25839.1HD-ZIP family protein
PHU26182.1HD-ZIP family protein
PHU26603.1HD-ZIP family protein
PHU26988.1HD-ZIP family protein
PHU27282.1HD-ZIP family protein
PHU27565.1HD-ZIP family protein
PHU27709.1HD-ZIP family protein
PHU27983.1HD-ZIP family protein
PHU28457.1HD-ZIP family protein
PHU28764.1HD-ZIP family protein
PHU29193.1HD-ZIP family protein
PHU29540.1HD-ZIP family protein
PHU30124.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401