PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Corchorus capsularis
HD-ZIP Family
Species TF ID Description
OMO50890HD-ZIP family protein
OMO51664HD-ZIP family protein
OMO54007HD-ZIP family protein
OMO54067HD-ZIP family protein
OMO56181HD-ZIP family protein
OMO56360HD-ZIP family protein
OMO56859HD-ZIP family protein
OMO57701HD-ZIP family protein
OMO58820HD-ZIP family protein
OMO59598HD-ZIP family protein
OMO60609HD-ZIP family protein
OMO62974HD-ZIP family protein
OMO64233HD-ZIP family protein
OMO67453HD-ZIP family protein
OMO69561HD-ZIP family protein
OMO74913HD-ZIP family protein
OMO75503HD-ZIP family protein
OMO76743HD-ZIP family protein
OMO77357HD-ZIP family protein
OMO78653HD-ZIP family protein
OMO79235HD-ZIP family protein
OMO79871HD-ZIP family protein
OMO80725HD-ZIP family protein
OMO83262HD-ZIP family protein
OMO86015HD-ZIP family protein
OMO93191HD-ZIP family protein
OMO95062HD-ZIP family protein
OMO96180HD-ZIP family protein
OMO96203HD-ZIP family protein
OMO96472HD-ZIP family protein
OMP06515HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401