PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Coffea arabica
MIKC_MADS Family
Species TF ID Description
XP_027063684.1MIKC_MADS family protein
XP_027063685.1MIKC_MADS family protein
XP_027069012.1MIKC_MADS family protein
XP_027069013.1MIKC_MADS family protein
XP_027073038.1MIKC_MADS family protein
XP_027073039.1MIKC_MADS family protein
XP_027073264.1MIKC_MADS family protein
XP_027074278.1MIKC_MADS family protein
XP_027074279.1MIKC_MADS family protein
XP_027074837.1MIKC_MADS family protein
XP_027074839.1MIKC_MADS family protein
XP_027075278.1MIKC_MADS family protein
XP_027075722.1MIKC_MADS family protein
XP_027076499.1MIKC_MADS family protein
XP_027076500.1MIKC_MADS family protein
XP_027076501.1MIKC_MADS family protein
XP_027076830.1MIKC_MADS family protein
XP_027077909.1MIKC_MADS family protein
XP_027077910.1MIKC_MADS family protein
XP_027078034.1MIKC_MADS family protein
XP_027078035.1MIKC_MADS family protein
XP_027078102.1MIKC_MADS family protein
XP_027078104.1MIKC_MADS family protein
XP_027078105.1MIKC_MADS family protein
XP_027078106.1MIKC_MADS family protein
XP_027078107.1MIKC_MADS family protein
XP_027078661.1MIKC_MADS family protein
XP_027078843.1MIKC_MADS family protein
XP_027078844.1MIKC_MADS family protein
XP_027080181.1MIKC_MADS family protein
XP_027082904.1MIKC_MADS family protein
XP_027083082.1MIKC_MADS family protein
XP_027085702.1MIKC_MADS family protein
XP_027085703.1MIKC_MADS family protein
XP_027085704.1MIKC_MADS family protein
XP_027086110.1MIKC_MADS family protein
XP_027086111.1MIKC_MADS family protein
XP_027086112.1MIKC_MADS family protein
XP_027088366.1MIKC_MADS family protein
XP_027088367.1MIKC_MADS family protein
XP_027089363.1MIKC_MADS family protein
XP_027089364.1MIKC_MADS family protein
XP_027089366.1MIKC_MADS family protein
XP_027089367.1MIKC_MADS family protein
XP_027089801.1MIKC_MADS family protein
XP_027089990.1MIKC_MADS family protein
XP_027090010.1MIKC_MADS family protein
XP_027090646.1MIKC_MADS family protein
XP_027090983.1MIKC_MADS family protein
XP_027091062.1MIKC_MADS family protein
XP_027091157.1MIKC_MADS family protein
XP_027091158.1MIKC_MADS family protein
XP_027091159.1MIKC_MADS family protein
XP_027091160.1MIKC_MADS family protein
XP_027091161.1MIKC_MADS family protein
XP_027091162.1MIKC_MADS family protein
XP_027091235.1MIKC_MADS family protein
XP_027092062.1MIKC_MADS family protein
XP_027092063.1MIKC_MADS family protein
XP_027092769.1MIKC_MADS family protein
XP_027092989.1MIKC_MADS family protein
XP_027092990.1MIKC_MADS family protein
XP_027093277.1MIKC_MADS family protein
XP_027093414.1MIKC_MADS family protein
XP_027093913.1MIKC_MADS family protein
XP_027093914.1MIKC_MADS family protein
XP_027093916.1MIKC_MADS family protein
XP_027093917.1MIKC_MADS family protein
XP_027093918.1MIKC_MADS family protein
XP_027093919.1MIKC_MADS family protein
XP_027094491.1MIKC_MADS family protein
XP_027094492.1MIKC_MADS family protein
XP_027094493.1MIKC_MADS family protein
XP_027094494.1MIKC_MADS family protein
XP_027096626.1MIKC_MADS family protein
XP_027096627.1MIKC_MADS family protein
XP_027096628.1MIKC_MADS family protein
XP_027096629.1MIKC_MADS family protein
XP_027096630.1MIKC_MADS family protein
XP_027096631.1MIKC_MADS family protein
XP_027096632.1MIKC_MADS family protein
XP_027096634.1MIKC_MADS family protein
XP_027096635.1MIKC_MADS family protein
XP_027096636.1MIKC_MADS family protein
XP_027096722.1MIKC_MADS family protein
XP_027096723.1MIKC_MADS family protein
XP_027097746.1MIKC_MADS family protein
XP_027099546.1MIKC_MADS family protein
XP_027099547.1MIKC_MADS family protein
XP_027099548.1MIKC_MADS family protein
XP_027099549.1MIKC_MADS family protein
XP_027100320.1MIKC_MADS family protein
XP_027101517.1MIKC_MADS family protein
XP_027101518.1MIKC_MADS family protein
XP_027101670.1MIKC_MADS family protein
XP_027103881.1MIKC_MADS family protein
XP_027106193.1MIKC_MADS family protein
XP_027106194.1MIKC_MADS family protein
XP_027106195.1MIKC_MADS family protein
XP_027106196.1MIKC_MADS family protein
XP_027106197.1MIKC_MADS family protein
XP_027108199.1MIKC_MADS family protein
XP_027109717.1MIKC_MADS family protein
XP_027110410.1MIKC_MADS family protein
XP_027112013.1MIKC_MADS family protein
XP_027112764.1MIKC_MADS family protein
XP_027112765.1MIKC_MADS family protein
XP_027112766.1MIKC_MADS family protein
XP_027112767.1MIKC_MADS family protein
XP_027112768.1MIKC_MADS family protein
XP_027113896.1MIKC_MADS family protein
XP_027115031.1MIKC_MADS family protein
XP_027115032.1MIKC_MADS family protein
XP_027125352.1MIKC_MADS family protein
XP_027125353.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513