PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Abrus precatorius
Species TF ID Description
XP_027329822.1MIKC_MADS family protein
XP_027329823.1MIKC_MADS family protein
XP_027330387.1MIKC_MADS family protein
XP_027330949.1MIKC_MADS family protein
XP_027331266.1MIKC_MADS family protein
XP_027332702.1MIKC_MADS family protein
XP_027333746.1MIKC_MADS family protein
XP_027333786.1MIKC_MADS family protein
XP_027333787.1MIKC_MADS family protein
XP_027334662.1MIKC_MADS family protein
XP_027334663.1MIKC_MADS family protein
XP_027334664.1MIKC_MADS family protein
XP_027334800.1MIKC_MADS family protein
XP_027335067.1MIKC_MADS family protein
XP_027335068.1MIKC_MADS family protein
XP_027335160.1MIKC_MADS family protein
XP_027335587.1MIKC_MADS family protein
XP_027335599.1MIKC_MADS family protein
XP_027335606.1MIKC_MADS family protein
XP_027338851.1MIKC_MADS family protein
XP_027339036.1MIKC_MADS family protein
XP_027339183.1MIKC_MADS family protein
XP_027339460.1MIKC_MADS family protein
XP_027339461.1MIKC_MADS family protein
XP_027339462.1MIKC_MADS family protein
XP_027339463.1MIKC_MADS family protein
XP_027339464.1MIKC_MADS family protein
XP_027339465.1MIKC_MADS family protein
XP_027339466.1MIKC_MADS family protein
XP_027339467.1MIKC_MADS family protein
XP_027339468.1MIKC_MADS family protein
XP_027339469.1MIKC_MADS family protein
XP_027339470.1MIKC_MADS family protein
XP_027340530.1MIKC_MADS family protein
XP_027340531.1MIKC_MADS family protein
XP_027340532.1MIKC_MADS family protein
XP_027340649.1MIKC_MADS family protein
XP_027340650.1MIKC_MADS family protein
XP_027341871.1MIKC_MADS family protein
XP_027345433.1MIKC_MADS family protein
XP_027345516.1MIKC_MADS family protein
XP_027345542.1MIKC_MADS family protein
XP_027347742.1MIKC_MADS family protein
XP_027348111.1MIKC_MADS family protein
XP_027348389.1MIKC_MADS family protein
XP_027348390.1MIKC_MADS family protein
XP_027348665.1MIKC_MADS family protein
XP_027353333.1MIKC_MADS family protein
XP_027353334.1MIKC_MADS family protein
XP_027353335.1MIKC_MADS family protein
XP_027355450.1MIKC_MADS family protein
XP_027355451.1MIKC_MADS family protein
XP_027355452.1MIKC_MADS family protein
XP_027355454.1MIKC_MADS family protein
XP_027356113.1MIKC_MADS family protein
XP_027356129.1MIKC_MADS family protein
XP_027356260.1MIKC_MADS family protein
XP_027357292.1MIKC_MADS family protein
XP_027357553.1MIKC_MADS family protein
XP_027357554.1MIKC_MADS family protein
XP_027357555.1MIKC_MADS family protein
XP_027357788.1MIKC_MADS family protein
XP_027357790.1MIKC_MADS family protein
XP_027359868.1MIKC_MADS family protein
XP_027360642.1MIKC_MADS family protein
XP_027361719.1MIKC_MADS family protein
XP_027361782.1MIKC_MADS family protein
XP_027361861.1MIKC_MADS family protein
XP_027362432.1MIKC_MADS family protein
XP_027362769.1MIKC_MADS family protein
XP_027364327.1MIKC_MADS family protein
XP_027364723.1MIKC_MADS family protein
XP_027364725.1MIKC_MADS family protein
XP_027368377.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513