PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Asparagus officinalis
bHLH Family
Species TF ID Description
evm.model.AsparagusV1_01.1007bHLH family protein
evm.model.AsparagusV1_01.1247bHLH family protein
evm.model.AsparagusV1_01.1472bHLH family protein
evm.model.AsparagusV1_01.2367bHLH family protein
evm.model.AsparagusV1_01.2554bHLH family protein
evm.model.AsparagusV1_01.2723bHLH family protein
evm.model.AsparagusV1_01.2737bHLH family protein
evm.model.AsparagusV1_01.2787bHLH family protein
evm.model.AsparagusV1_01.2944bHLH family protein
evm.model.AsparagusV1_01.3328bHLH family protein
evm.model.AsparagusV1_01.3639bHLH family protein
evm.model.AsparagusV1_01.569bHLH family protein
evm.model.AsparagusV1_01.635bHLH family protein
evm.model.AsparagusV1_01.782bHLH family protein
evm.model.AsparagusV1_02.1016bHLH family protein
evm.model.AsparagusV1_02.1124bHLH family protein
evm.model.AsparagusV1_02.1212bHLH family protein
evm.model.AsparagusV1_02.1522bHLH family protein
evm.model.AsparagusV1_02.1606bHLH family protein
evm.model.AsparagusV1_02.1668bHLH family protein
evm.model.AsparagusV1_02.1902bHLH family protein
evm.model.AsparagusV1_02.2062bHLH family protein
evm.model.AsparagusV1_02.2269bHLH family protein
evm.model.AsparagusV1_02.270bHLH family protein
evm.model.AsparagusV1_02.451bHLH family protein
evm.model.AsparagusV1_02.743bHLH family protein
evm.model.AsparagusV1_02.896bHLH family protein
evm.model.AsparagusV1_03.1038bHLH family protein
evm.model.AsparagusV1_03.1407bHLH family protein
evm.model.AsparagusV1_03.1708bHLH family protein
evm.model.AsparagusV1_03.1804bHLH family protein
evm.model.AsparagusV1_03.1873bHLH family protein
evm.model.AsparagusV1_03.1905bHLH family protein
evm.model.AsparagusV1_03.2136bHLH family protein
evm.model.AsparagusV1_03.2178bHLH family protein
evm.model.AsparagusV1_03.2376bHLH family protein
evm.model.AsparagusV1_03.2764bHLH family protein
evm.model.AsparagusV1_03.3193bHLH family protein
evm.model.AsparagusV1_03.330bHLH family protein
evm.model.AsparagusV1_03.383bHLH family protein
evm.model.AsparagusV1_03.596bHLH family protein
evm.model.AsparagusV1_03.73bHLH family protein
evm.model.AsparagusV1_03.768bHLH family protein
evm.model.AsparagusV1_03.79bHLH family protein
evm.model.AsparagusV1_03.908bHLH family protein
evm.model.AsparagusV1_03.947bHLH family protein
evm.model.AsparagusV1_03.995bHLH family protein
evm.model.AsparagusV1_04.1229bHLH family protein
evm.model.AsparagusV1_04.1557bHLH family protein
evm.model.AsparagusV1_04.1698bHLH family protein
evm.model.AsparagusV1_04.1803bHLH family protein
evm.model.AsparagusV1_04.550bHLH family protein
evm.model.AsparagusV1_04.744bHLH family protein
evm.model.AsparagusV1_04.928bHLH family protein
evm.model.AsparagusV1_04.930bHLH family protein
evm.model.AsparagusV1_04.942bHLH family protein
evm.model.AsparagusV1_05.139bHLH family protein
evm.model.AsparagusV1_05.1417bHLH family protein
evm.model.AsparagusV1_05.2048bHLH family protein
evm.model.AsparagusV1_05.2233bHLH family protein
evm.model.AsparagusV1_05.2246bHLH family protein
evm.model.AsparagusV1_05.2397bHLH family protein
evm.model.AsparagusV1_05.2409bHLH family protein
evm.model.AsparagusV1_05.2412bHLH family protein
evm.model.AsparagusV1_05.251bHLH family protein
evm.model.AsparagusV1_05.3002bHLH family protein
evm.model.AsparagusV1_05.613bHLH family protein
evm.model.AsparagusV1_05.65bHLH family protein
evm.model.AsparagusV1_06.1298bHLH family protein
evm.model.AsparagusV1_06.1754bHLH family protein
evm.model.AsparagusV1_06.1823bHLH family protein
evm.model.AsparagusV1_06.1949bHLH family protein
evm.model.AsparagusV1_06.236bHLH family protein
evm.model.AsparagusV1_06.588bHLH family protein
evm.model.AsparagusV1_06.597bHLH family protein
evm.model.AsparagusV1_07.1066bHLH family protein
evm.model.AsparagusV1_07.1108bHLH family protein
evm.model.AsparagusV1_07.1423bHLH family protein
evm.model.AsparagusV1_07.1632bHLH family protein
evm.model.AsparagusV1_07.1634bHLH family protein
evm.model.AsparagusV1_07.1636bHLH family protein
evm.model.AsparagusV1_07.2467bHLH family protein
evm.model.AsparagusV1_07.2491bHLH family protein
evm.model.AsparagusV1_07.2575bHLH family protein
evm.model.AsparagusV1_07.268bHLH family protein
evm.model.AsparagusV1_07.3140bHLH family protein
evm.model.AsparagusV1_07.3195bHLH family protein
evm.model.AsparagusV1_07.3516bHLH family protein
evm.model.AsparagusV1_07.3861bHLH family protein
evm.model.AsparagusV1_07.3901bHLH family protein
evm.model.AsparagusV1_07.3911bHLH family protein
evm.model.AsparagusV1_07.430bHLH family protein
evm.model.AsparagusV1_07.555bHLH family protein
evm.model.AsparagusV1_08.1262bHLH family protein
evm.model.AsparagusV1_08.1428bHLH family protein
evm.model.AsparagusV1_08.1635bHLH family protein
evm.model.AsparagusV1_08.1856bHLH family protein
evm.model.AsparagusV1_08.2409bHLH family protein
evm.model.AsparagusV1_08.2640bHLH family protein
evm.model.AsparagusV1_08.2699bHLH family protein
evm.model.AsparagusV1_08.2989bHLH family protein
evm.model.AsparagusV1_08.299bHLH family protein
evm.model.AsparagusV1_08.3045bHLH family protein
evm.model.AsparagusV1_08.3407bHLH family protein
evm.model.AsparagusV1_08.3614bHLH family protein
evm.model.AsparagusV1_08.468bHLH family protein
evm.model.AsparagusV1_09.1355bHLH family protein
evm.model.AsparagusV1_09.1462bHLH family protein
evm.model.AsparagusV1_09.570bHLH family protein
evm.model.AsparagusV1_09.596bHLH family protein
evm.model.AsparagusV1_09.607bHLH family protein
evm.model.AsparagusV1_09.609bHLH family protein
evm.model.AsparagusV1_10.1176bHLH family protein
evm.model.AsparagusV1_10.1666bHLH family protein
evm.model.AsparagusV1_10.1691bHLH family protein
evm.model.AsparagusV1_Unassigned.1070bHLH family protein
evm.model.AsparagusV1_Unassigned.619bHLH family protein
evm.model.AsparagusV1_Unassigned.849bHLH family protein
evm.model.AsparagusV1_Unassigned.852bHLH family protein
evm.model.AsparagusV1_Unassigned.978bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250