PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Zea mays
Species TF ID Description
AC233912.1_FGP001MIKC_MADS family protein
GRMZM2G001139_P01MIKC_MADS family protein
GRMZM2G001139_P02MIKC_MADS family protein
GRMZM2G001139_P03MIKC_MADS family protein
GRMZM2G003514_P01MIKC_MADS family protein
GRMZM2G005155_P01MIKC_MADS family protein
GRMZM2G005155_P02MIKC_MADS family protein
GRMZM2G005155_P03MIKC_MADS family protein
GRMZM2G010669_P01MIKC_MADS family protein
GRMZM2G010669_P02MIKC_MADS family protein
GRMZM2G010669_P03MIKC_MADS family protein
GRMZM2G018589_P01MIKC_MADS family protein
GRMZM2G026223_P01MIKC_MADS family protein
GRMZM2G026223_P02MIKC_MADS family protein
GRMZM2G026223_P03MIKC_MADS family protein
GRMZM2G026223_P04MIKC_MADS family protein
GRMZM2G026223_P05MIKC_MADS family protein
GRMZM2G026223_P06MIKC_MADS family protein
GRMZM2G026223_P07MIKC_MADS family protein
GRMZM2G032339_P02MIKC_MADS family protein
GRMZM2G032339_P03MIKC_MADS family protein
GRMZM2G032339_P04MIKC_MADS family protein
GRMZM2G046885_P01MIKC_MADS family protein
GRMZM2G046885_P02MIKC_MADS family protein
GRMZM2G052890_P01MIKC_MADS family protein
GRMZM2G059102_P01MIKC_MADS family protein
GRMZM2G059102_P02MIKC_MADS family protein
GRMZM2G059102_P03MIKC_MADS family protein
GRMZM2G059102_P04MIKC_MADS family protein
GRMZM2G069370_P01MIKC_MADS family protein
GRMZM2G070034_P01MIKC_MADS family protein
GRMZM2G070034_P02MIKC_MADS family protein
GRMZM2G071620_P01MIKC_MADS family protein
GRMZM2G072582_P02MIKC_MADS family protein
GRMZM2G079727_P01MIKC_MADS family protein
GRMZM2G079727_P02MIKC_MADS family protein
GRMZM2G087095_P01MIKC_MADS family protein
GRMZM2G097059_P01MIKC_MADS family protein
GRMZM2G099522_P01MIKC_MADS family protein
GRMZM2G099522_P02MIKC_MADS family protein
GRMZM2G102161_P01MIKC_MADS family protein
GRMZM2G105387_P02MIKC_MADS family protein
GRMZM2G105387_P03MIKC_MADS family protein
GRMZM2G105387_P04MIKC_MADS family protein
GRMZM2G110153_P01MIKC_MADS family protein
GRMZM2G117961_P01MIKC_MADS family protein
GRMZM2G128953_P01MIKC_MADS family protein
GRMZM2G128953_P02MIKC_MADS family protein
GRMZM2G129034_P01MIKC_MADS family protein
GRMZM2G129034_P02MIKC_MADS family protein
GRMZM2G135018_P01MIKC_MADS family protein
GRMZM2G137387_P01MIKC_MADS family protein
GRMZM2G137510_P01MIKC_MADS family protein
GRMZM2G137510_P02MIKC_MADS family protein
GRMZM2G137510_P03MIKC_MADS family protein
GRMZM2G139073_P01MIKC_MADS family protein
GRMZM2G147716_P01MIKC_MADS family protein
GRMZM2G148220_P01MIKC_MADS family protein
GRMZM2G148220_P02MIKC_MADS family protein
GRMZM2G148693_P01MIKC_MADS family protein
GRMZM2G148693_P02MIKC_MADS family protein
GRMZM2G152862_P01MIKC_MADS family protein
GRMZM2G152862_P02MIKC_MADS family protein
GRMZM2G159397_P01MIKC_MADS family protein
GRMZM2G160565_P01MIKC_MADS family protein
GRMZM2G160687_P01MIKC_MADS family protein
GRMZM2G160687_P02MIKC_MADS family protein
GRMZM2G160687_P03MIKC_MADS family protein
GRMZM2G161666_P01MIKC_MADS family protein
GRMZM2G171365_P01MIKC_MADS family protein
GRMZM2G171365_P03MIKC_MADS family protein
GRMZM2G171365_P04MIKC_MADS family protein
GRMZM2G334225_P01MIKC_MADS family protein
GRMZM2G359952_P01MIKC_MADS family protein
GRMZM2G359952_P02MIKC_MADS family protein
GRMZM2G370777_P01MIKC_MADS family protein
GRMZM2G370777_P02MIKC_MADS family protein
GRMZM2G370777_P03MIKC_MADS family protein
GRMZM2G553379_P02MIKC_MADS family protein
GRMZM2G553379_P03MIKC_MADS family protein
GRMZM2G553379_P04MIKC_MADS family protein
GRMZM2G553379_P05MIKC_MADS family protein
GRMZM2G553379_P06MIKC_MADS family protein
GRMZM2G553379_P07MIKC_MADS family protein
GRMZM2G553379_P08MIKC_MADS family protein
GRMZM5G805387_P01MIKC_MADS family protein
GRMZM5G805387_P02MIKC_MADS family protein
GRMZM5G805387_P03MIKC_MADS family protein
GRMZM5G814279_P01MIKC_MADS family protein
GRMZM5G814279_P02MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513