PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Zea mays
M-type_MADS Family
Species TF ID Description
AC212823.4_FGP003M-type_MADS family protein
AC234185.1_FGP006M-type_MADS family protein
GRMZM2G032905_P01M-type_MADS family protein
GRMZM2G035092_P01M-type_MADS family protein
GRMZM2G038878_P01M-type_MADS family protein
GRMZM2G044408_P01M-type_MADS family protein
GRMZM2G052045_P01M-type_MADS family protein
GRMZM2G055782_P01M-type_MADS family protein
GRMZM2G072582_P03M-type_MADS family protein
GRMZM2G073357_P01M-type_MADS family protein
GRMZM2G098986_P01M-type_MADS family protein
GRMZM2G099408_P01M-type_MADS family protein
GRMZM2G099577_P01M-type_MADS family protein
GRMZM2G105387_P01M-type_MADS family protein
GRMZM2G110582_P03M-type_MADS family protein
GRMZM2G110582_P04M-type_MADS family protein
GRMZM2G130382_P01M-type_MADS family protein
GRMZM2G137289_P01M-type_MADS family protein
GRMZM2G147716_P02M-type_MADS family protein
GRMZM2G152415_P01M-type_MADS family protein
GRMZM2G152862_P03M-type_MADS family protein
GRMZM2G152862_P04M-type_MADS family protein
GRMZM2G171365_P02M-type_MADS family protein
GRMZM2G171650_P01M-type_MADS family protein
GRMZM2G171650_P02M-type_MADS family protein
GRMZM2G171650_P03M-type_MADS family protein
GRMZM2G171650_P04M-type_MADS family protein
GRMZM2G171650_P05M-type_MADS family protein
GRMZM2G306610_P01M-type_MADS family protein
GRMZM2G316366_P01M-type_MADS family protein
GRMZM2G320549_P01M-type_MADS family protein
GRMZM2G320549_P02M-type_MADS family protein
GRMZM2G334225_P02M-type_MADS family protein
GRMZM2G337892_P01M-type_MADS family protein
GRMZM2G375707_P01M-type_MADS family protein
GRMZM2G441115_P01M-type_MADS family protein
GRMZM2G446426_P01M-type_MADS family protein
GRMZM2G459864_P01M-type_MADS family protein
GRMZM2G472096_P01M-type_MADS family protein
GRMZM2G472100_P01M-type_MADS family protein
GRMZM2G531231_P01M-type_MADS family protein
GRMZM2G553379_P01M-type_MADS family protein
GRMZM5G839969_P01M-type_MADS family protein
GRMZM5G853066_P01M-type_MADS family protein
GRMZM5G878490_P01M-type_MADS family protein
GRMZM5G891280_P01M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513