PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Trifolium pratense
bHLH Family
Species TF ID Description
Tp57577_TGAC_v2_mRNA10155bHLH family protein
Tp57577_TGAC_v2_mRNA10365bHLH family protein
Tp57577_TGAC_v2_mRNA1051bHLH family protein
Tp57577_TGAC_v2_mRNA11169bHLH family protein
Tp57577_TGAC_v2_mRNA11571bHLH family protein
Tp57577_TGAC_v2_mRNA11923bHLH family protein
Tp57577_TGAC_v2_mRNA12075bHLH family protein
Tp57577_TGAC_v2_mRNA12077bHLH family protein
Tp57577_TGAC_v2_mRNA12114bHLH family protein
Tp57577_TGAC_v2_mRNA12264bHLH family protein
Tp57577_TGAC_v2_mRNA12638bHLH family protein
Tp57577_TGAC_v2_mRNA12809bHLH family protein
Tp57577_TGAC_v2_mRNA12817bHLH family protein
Tp57577_TGAC_v2_mRNA13145bHLH family protein
Tp57577_TGAC_v2_mRNA13172bHLH family protein
Tp57577_TGAC_v2_mRNA13247bHLH family protein
Tp57577_TGAC_v2_mRNA13360bHLH family protein
Tp57577_TGAC_v2_mRNA13513bHLH family protein
Tp57577_TGAC_v2_mRNA13514bHLH family protein
Tp57577_TGAC_v2_mRNA13866bHLH family protein
Tp57577_TGAC_v2_mRNA14103bHLH family protein
Tp57577_TGAC_v2_mRNA14379bHLH family protein
Tp57577_TGAC_v2_mRNA14386bHLH family protein
Tp57577_TGAC_v2_mRNA14392bHLH family protein
Tp57577_TGAC_v2_mRNA15240bHLH family protein
Tp57577_TGAC_v2_mRNA15680bHLH family protein
Tp57577_TGAC_v2_mRNA1596bHLH family protein
Tp57577_TGAC_v2_mRNA16404bHLH family protein
Tp57577_TGAC_v2_mRNA16426bHLH family protein
Tp57577_TGAC_v2_mRNA1686bHLH family protein
Tp57577_TGAC_v2_mRNA17023bHLH family protein
Tp57577_TGAC_v2_mRNA17086bHLH family protein
Tp57577_TGAC_v2_mRNA17469bHLH family protein
Tp57577_TGAC_v2_mRNA17746bHLH family protein
Tp57577_TGAC_v2_mRNA18002bHLH family protein
Tp57577_TGAC_v2_mRNA18029bHLH family protein
Tp57577_TGAC_v2_mRNA18047bHLH family protein
Tp57577_TGAC_v2_mRNA18074bHLH family protein
Tp57577_TGAC_v2_mRNA19740bHLH family protein
Tp57577_TGAC_v2_mRNA19799bHLH family protein
Tp57577_TGAC_v2_mRNA19805bHLH family protein
Tp57577_TGAC_v2_mRNA19816bHLH family protein
Tp57577_TGAC_v2_mRNA2023bHLH family protein
Tp57577_TGAC_v2_mRNA20300bHLH family protein
Tp57577_TGAC_v2_mRNA20325bHLH family protein
Tp57577_TGAC_v2_mRNA20326bHLH family protein
Tp57577_TGAC_v2_mRNA20705bHLH family protein
Tp57577_TGAC_v2_mRNA20937bHLH family protein
Tp57577_TGAC_v2_mRNA21288bHLH family protein
Tp57577_TGAC_v2_mRNA21747bHLH family protein
Tp57577_TGAC_v2_mRNA22319bHLH family protein
Tp57577_TGAC_v2_mRNA22327bHLH family protein
Tp57577_TGAC_v2_mRNA22470bHLH family protein
Tp57577_TGAC_v2_mRNA22942bHLH family protein
Tp57577_TGAC_v2_mRNA23188bHLH family protein
Tp57577_TGAC_v2_mRNA23191bHLH family protein
Tp57577_TGAC_v2_mRNA23192bHLH family protein
Tp57577_TGAC_v2_mRNA23194bHLH family protein
Tp57577_TGAC_v2_mRNA23195bHLH family protein
Tp57577_TGAC_v2_mRNA23200bHLH family protein
Tp57577_TGAC_v2_mRNA23250bHLH family protein
Tp57577_TGAC_v2_mRNA23501bHLH family protein
Tp57577_TGAC_v2_mRNA23716bHLH family protein
Tp57577_TGAC_v2_mRNA24049bHLH family protein
Tp57577_TGAC_v2_mRNA24323bHLH family protein
Tp57577_TGAC_v2_mRNA24336bHLH family protein
Tp57577_TGAC_v2_mRNA24662bHLH family protein
Tp57577_TGAC_v2_mRNA2494bHLH family protein
Tp57577_TGAC_v2_mRNA25041bHLH family protein
Tp57577_TGAC_v2_mRNA26222bHLH family protein
Tp57577_TGAC_v2_mRNA26528bHLH family protein
Tp57577_TGAC_v2_mRNA26813bHLH family protein
Tp57577_TGAC_v2_mRNA26902bHLH family protein
Tp57577_TGAC_v2_mRNA26903bHLH family protein
Tp57577_TGAC_v2_mRNA27470bHLH family protein
Tp57577_TGAC_v2_mRNA27493bHLH family protein
Tp57577_TGAC_v2_mRNA27649bHLH family protein
Tp57577_TGAC_v2_mRNA2781bHLH family protein
Tp57577_TGAC_v2_mRNA2782bHLH family protein
Tp57577_TGAC_v2_mRNA28042bHLH family protein
Tp57577_TGAC_v2_mRNA28059bHLH family protein
Tp57577_TGAC_v2_mRNA2831bHLH family protein
Tp57577_TGAC_v2_mRNA28436bHLH family protein
Tp57577_TGAC_v2_mRNA28440bHLH family protein
Tp57577_TGAC_v2_mRNA28629bHLH family protein
Tp57577_TGAC_v2_mRNA28699bHLH family protein
Tp57577_TGAC_v2_mRNA28849bHLH family protein
Tp57577_TGAC_v2_mRNA28980bHLH family protein
Tp57577_TGAC_v2_mRNA29027bHLH family protein
Tp57577_TGAC_v2_mRNA29165bHLH family protein
Tp57577_TGAC_v2_mRNA29753bHLH family protein
Tp57577_TGAC_v2_mRNA30161bHLH family protein
Tp57577_TGAC_v2_mRNA30436bHLH family protein
Tp57577_TGAC_v2_mRNA30785bHLH family protein
Tp57577_TGAC_v2_mRNA31005bHLH family protein
Tp57577_TGAC_v2_mRNA31183bHLH family protein
Tp57577_TGAC_v2_mRNA31464bHLH family protein
Tp57577_TGAC_v2_mRNA31702bHLH family protein
Tp57577_TGAC_v2_mRNA31747bHLH family protein
Tp57577_TGAC_v2_mRNA31840bHLH family protein
Tp57577_TGAC_v2_mRNA31842bHLH family protein
Tp57577_TGAC_v2_mRNA33215bHLH family protein
Tp57577_TGAC_v2_mRNA33818bHLH family protein
Tp57577_TGAC_v2_mRNA3422bHLH family protein
Tp57577_TGAC_v2_mRNA34236bHLH family protein
Tp57577_TGAC_v2_mRNA34351bHLH family protein
Tp57577_TGAC_v2_mRNA34414bHLH family protein
Tp57577_TGAC_v2_mRNA34443bHLH family protein
Tp57577_TGAC_v2_mRNA34811bHLH family protein
Tp57577_TGAC_v2_mRNA34960bHLH family protein
Tp57577_TGAC_v2_mRNA35910bHLH family protein
Tp57577_TGAC_v2_mRNA3594bHLH family protein
Tp57577_TGAC_v2_mRNA36093bHLH family protein
Tp57577_TGAC_v2_mRNA36094bHLH family protein
Tp57577_TGAC_v2_mRNA37655bHLH family protein
Tp57577_TGAC_v2_mRNA37656bHLH family protein
Tp57577_TGAC_v2_mRNA38070bHLH family protein
Tp57577_TGAC_v2_mRNA38079bHLH family protein
Tp57577_TGAC_v2_mRNA38310bHLH family protein
Tp57577_TGAC_v2_mRNA38409bHLH family protein
Tp57577_TGAC_v2_mRNA38410bHLH family protein
Tp57577_TGAC_v2_mRNA38549bHLH family protein
Tp57577_TGAC_v2_mRNA3907bHLH family protein
Tp57577_TGAC_v2_mRNA3916bHLH family protein
Tp57577_TGAC_v2_mRNA39511bHLH family protein
Tp57577_TGAC_v2_mRNA39617bHLH family protein
Tp57577_TGAC_v2_mRNA39750bHLH family protein
Tp57577_TGAC_v2_mRNA39751bHLH family protein
Tp57577_TGAC_v2_mRNA40009bHLH family protein
Tp57577_TGAC_v2_mRNA40010bHLH family protein
Tp57577_TGAC_v2_mRNA40361bHLH family protein
Tp57577_TGAC_v2_mRNA40362bHLH family protein
Tp57577_TGAC_v2_mRNA40363bHLH family protein
Tp57577_TGAC_v2_mRNA40364bHLH family protein
Tp57577_TGAC_v2_mRNA40372bHLH family protein
Tp57577_TGAC_v2_mRNA40520bHLH family protein
Tp57577_TGAC_v2_mRNA40521bHLH family protein
Tp57577_TGAC_v2_mRNA41509bHLH family protein
Tp57577_TGAC_v2_mRNA41566bHLH family protein
Tp57577_TGAC_v2_mRNA41590bHLH family protein
Tp57577_TGAC_v2_mRNA4394bHLH family protein
Tp57577_TGAC_v2_mRNA4906bHLH family protein
Tp57577_TGAC_v2_mRNA4925bHLH family protein
Tp57577_TGAC_v2_mRNA4955bHLH family protein
Tp57577_TGAC_v2_mRNA5945bHLH family protein
Tp57577_TGAC_v2_mRNA5946bHLH family protein
Tp57577_TGAC_v2_mRNA6230bHLH family protein
Tp57577_TGAC_v2_mRNA6576bHLH family protein
Tp57577_TGAC_v2_mRNA6640bHLH family protein
Tp57577_TGAC_v2_mRNA6823bHLH family protein
Tp57577_TGAC_v2_mRNA709bHLH family protein
Tp57577_TGAC_v2_mRNA7093bHLH family protein
Tp57577_TGAC_v2_mRNA7822bHLH family protein
Tp57577_TGAC_v2_mRNA7823bHLH family protein
Tp57577_TGAC_v2_mRNA7824bHLH family protein
Tp57577_TGAC_v2_mRNA7832bHLH family protein
Tp57577_TGAC_v2_mRNA8597bHLH family protein
Tp57577_TGAC_v2_mRNA8683bHLH family protein
Tp57577_TGAC_v2_mRNA9049bHLH family protein
Tp57577_TGAC_v2_mRNA9183bHLH family protein
Tp57577_TGAC_v2_mRNA9206bHLH family protein
Tp57577_TGAC_v2_mRNA9423bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250