PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Solanum tuberosum
bHLH Family
Species TF ID Description
PGSC0003DMP400000489bHLH family protein
PGSC0003DMP400000490bHLH family protein
PGSC0003DMP400000652bHLH family protein
PGSC0003DMP400000653bHLH family protein
PGSC0003DMP400001205bHLH family protein
PGSC0003DMP400001206bHLH family protein
PGSC0003DMP400001388bHLH family protein
PGSC0003DMP400001390bHLH family protein
PGSC0003DMP400001570bHLH family protein
PGSC0003DMP400001571bHLH family protein
PGSC0003DMP400001828bHLH family protein
PGSC0003DMP400002142bHLH family protein
PGSC0003DMP400002559bHLH family protein
PGSC0003DMP400002886bHLH family protein
PGSC0003DMP400002887bHLH family protein
PGSC0003DMP400003204bHLH family protein
PGSC0003DMP400003676bHLH family protein
PGSC0003DMP400003806bHLH family protein
PGSC0003DMP400003807bHLH family protein
PGSC0003DMP400004456bHLH family protein
PGSC0003DMP400004457bHLH family protein
PGSC0003DMP400004458bHLH family protein
PGSC0003DMP400004713bHLH family protein
PGSC0003DMP400005168bHLH family protein
PGSC0003DMP400005823bHLH family protein
PGSC0003DMP400006687bHLH family protein
PGSC0003DMP400006688bHLH family protein
PGSC0003DMP400006689bHLH family protein
PGSC0003DMP400007151bHLH family protein
PGSC0003DMP400007152bHLH family protein
PGSC0003DMP400007209bHLH family protein
PGSC0003DMP400007246bHLH family protein
PGSC0003DMP400007304bHLH family protein
PGSC0003DMP400007305bHLH family protein
PGSC0003DMP400008095bHLH family protein
PGSC0003DMP400008096bHLH family protein
PGSC0003DMP400008672bHLH family protein
PGSC0003DMP400008749bHLH family protein
PGSC0003DMP400008750bHLH family protein
PGSC0003DMP400008751bHLH family protein
PGSC0003DMP400009023bHLH family protein
PGSC0003DMP400009069bHLH family protein
PGSC0003DMP400009531bHLH family protein
PGSC0003DMP400009532bHLH family protein
PGSC0003DMP400010146bHLH family protein
PGSC0003DMP400010389bHLH family protein
PGSC0003DMP400010653bHLH family protein
PGSC0003DMP400010802bHLH family protein
PGSC0003DMP400011341bHLH family protein
PGSC0003DMP400011342bHLH family protein
PGSC0003DMP400011343bHLH family protein
PGSC0003DMP400011610bHLH family protein
PGSC0003DMP400011611bHLH family protein
PGSC0003DMP400012200bHLH family protein
PGSC0003DMP400012418bHLH family protein
PGSC0003DMP400012579bHLH family protein
PGSC0003DMP400013372bHLH family protein
PGSC0003DMP400013796bHLH family protein
PGSC0003DMP400013989bHLH family protein
PGSC0003DMP400013990bHLH family protein
PGSC0003DMP400013991bHLH family protein
PGSC0003DMP400014007bHLH family protein
PGSC0003DMP400014008bHLH family protein
PGSC0003DMP400014343bHLH family protein
PGSC0003DMP400014389bHLH family protein
PGSC0003DMP400014411bHLH family protein
PGSC0003DMP400014412bHLH family protein
PGSC0003DMP400014551bHLH family protein
PGSC0003DMP400014704bHLH family protein
PGSC0003DMP400016023bHLH family protein
PGSC0003DMP400016517bHLH family protein
PGSC0003DMP400018055bHLH family protein
PGSC0003DMP400018367bHLH family protein
PGSC0003DMP400018368bHLH family protein
PGSC0003DMP400018369bHLH family protein
PGSC0003DMP400018618bHLH family protein
PGSC0003DMP400019126bHLH family protein
PGSC0003DMP400019127bHLH family protein
PGSC0003DMP400019655bHLH family protein
PGSC0003DMP400021649bHLH family protein
PGSC0003DMP400021841bHLH family protein
PGSC0003DMP400021842bHLH family protein
PGSC0003DMP400022834bHLH family protein
PGSC0003DMP400022848bHLH family protein
PGSC0003DMP400022973bHLH family protein
PGSC0003DMP400023696bHLH family protein
PGSC0003DMP400023697bHLH family protein
PGSC0003DMP400023698bHLH family protein
PGSC0003DMP400023700bHLH family protein
PGSC0003DMP400024468bHLH family protein
PGSC0003DMP400024469bHLH family protein
PGSC0003DMP400025090bHLH family protein
PGSC0003DMP400025430bHLH family protein
PGSC0003DMP400025668bHLH family protein
PGSC0003DMP400025669bHLH family protein
PGSC0003DMP400025910bHLH family protein
PGSC0003DMP400025911bHLH family protein
PGSC0003DMP400025912bHLH family protein
PGSC0003DMP400027130bHLH family protein
PGSC0003DMP400027441bHLH family protein
PGSC0003DMP400027642bHLH family protein
PGSC0003DMP400027896bHLH family protein
PGSC0003DMP400027897bHLH family protein
PGSC0003DMP400028197bHLH family protein
PGSC0003DMP400029023bHLH family protein
PGSC0003DMP400029024bHLH family protein
PGSC0003DMP400029998bHLH family protein
PGSC0003DMP400030471bHLH family protein
PGSC0003DMP400030626bHLH family protein
PGSC0003DMP400030631bHLH family protein
PGSC0003DMP400031052bHLH family protein
PGSC0003DMP400031849bHLH family protein
PGSC0003DMP400031850bHLH family protein
PGSC0003DMP400031944bHLH family protein
PGSC0003DMP400032987bHLH family protein
PGSC0003DMP400032989bHLH family protein
PGSC0003DMP400032990bHLH family protein
PGSC0003DMP400033040bHLH family protein
PGSC0003DMP400033079bHLH family protein
PGSC0003DMP400033417bHLH family protein
PGSC0003DMP400033471bHLH family protein
PGSC0003DMP400033472bHLH family protein
PGSC0003DMP400033590bHLH family protein
PGSC0003DMP400034148bHLH family protein
PGSC0003DMP400034149bHLH family protein
PGSC0003DMP400034157bHLH family protein
PGSC0003DMP400034158bHLH family protein
PGSC0003DMP400034159bHLH family protein
PGSC0003DMP400034485bHLH family protein
PGSC0003DMP400034788bHLH family protein
PGSC0003DMP400034789bHLH family protein
PGSC0003DMP400034790bHLH family protein
PGSC0003DMP400034791bHLH family protein
PGSC0003DMP400035017bHLH family protein
PGSC0003DMP400035479bHLH family protein
PGSC0003DMP400036170bHLH family protein
PGSC0003DMP400036180bHLH family protein
PGSC0003DMP400037320bHLH family protein
PGSC0003DMP400037645bHLH family protein
PGSC0003DMP400037646bHLH family protein
PGSC0003DMP400037647bHLH family protein
PGSC0003DMP400038123bHLH family protein
PGSC0003DMP400038140bHLH family protein
PGSC0003DMP400039140bHLH family protein
PGSC0003DMP400039142bHLH family protein
PGSC0003DMP400039161bHLH family protein
PGSC0003DMP400039162bHLH family protein
PGSC0003DMP400039949bHLH family protein
PGSC0003DMP400040805bHLH family protein
PGSC0003DMP400041251bHLH family protein
PGSC0003DMP400041252bHLH family protein
PGSC0003DMP400042289bHLH family protein
PGSC0003DMP400042290bHLH family protein
PGSC0003DMP400042291bHLH family protein
PGSC0003DMP400042418bHLH family protein
PGSC0003DMP400042420bHLH family protein
PGSC0003DMP400042421bHLH family protein
PGSC0003DMP400042484bHLH family protein
PGSC0003DMP400042485bHLH family protein
PGSC0003DMP400043420bHLH family protein
PGSC0003DMP400043421bHLH family protein
PGSC0003DMP400043846bHLH family protein
PGSC0003DMP400044661bHLH family protein
PGSC0003DMP400044662bHLH family protein
PGSC0003DMP400044663bHLH family protein
PGSC0003DMP400044664bHLH family protein
PGSC0003DMP400045048bHLH family protein
PGSC0003DMP400045049bHLH family protein
PGSC0003DMP400045399bHLH family protein
PGSC0003DMP400045403bHLH family protein
PGSC0003DMP400045404bHLH family protein
PGSC0003DMP400046965bHLH family protein
PGSC0003DMP400046966bHLH family protein
PGSC0003DMP400046967bHLH family protein
PGSC0003DMP400048214bHLH family protein
PGSC0003DMP400048605bHLH family protein
PGSC0003DMP400048631bHLH family protein
PGSC0003DMP400049785bHLH family protein
PGSC0003DMP400049927bHLH family protein
PGSC0003DMP400050144bHLH family protein
PGSC0003DMP400050145bHLH family protein
PGSC0003DMP400050146bHLH family protein
PGSC0003DMP400051622bHLH family protein
PGSC0003DMP400051623bHLH family protein
PGSC0003DMP400051624bHLH family protein
PGSC0003DMP400052017bHLH family protein
PGSC0003DMP400052018bHLH family protein
PGSC0003DMP400052021bHLH family protein
PGSC0003DMP400053318bHLH family protein
PGSC0003DMP400053329bHLH family protein
PGSC0003DMP400053330bHLH family protein
PGSC0003DMP400053331bHLH family protein
PGSC0003DMP400053332bHLH family protein
PGSC0003DMP400053333bHLH family protein
PGSC0003DMP400053393bHLH family protein
PGSC0003DMP400054552bHLH family protein
PGSC0003DMP400054553bHLH family protein
PGSC0003DMP400055864bHLH family protein
PGSC0003DMP400056643bHLH family protein
PGSC0003DMP400058538bHLH family protein
PGSC0003DMP400058818bHLH family protein
PGSC0003DMP400061403bHLH family protein
PGSC0003DMP400062939bHLH family protein
PGSC0003DMP400065842bHLH family protein
PGSC0003DMP400066978bHLH family protein
PGSC0003DMP400067113bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250