PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Solanum tuberosum
HD-ZIP Family
Species TF ID Description
PGSC0003DMP400000519HD-ZIP family protein
PGSC0003DMP400000971HD-ZIP family protein
PGSC0003DMP400001648HD-ZIP family protein
PGSC0003DMP400001649HD-ZIP family protein
PGSC0003DMP400002556HD-ZIP family protein
PGSC0003DMP400002557HD-ZIP family protein
PGSC0003DMP400002558HD-ZIP family protein
PGSC0003DMP400003710HD-ZIP family protein
PGSC0003DMP400004266HD-ZIP family protein
PGSC0003DMP400004679HD-ZIP family protein
PGSC0003DMP400004700HD-ZIP family protein
PGSC0003DMP400004701HD-ZIP family protein
PGSC0003DMP400004825HD-ZIP family protein
PGSC0003DMP400005129HD-ZIP family protein
PGSC0003DMP400005130HD-ZIP family protein
PGSC0003DMP400007968HD-ZIP family protein
PGSC0003DMP400008768HD-ZIP family protein
PGSC0003DMP400009655HD-ZIP family protein
PGSC0003DMP400011195HD-ZIP family protein
PGSC0003DMP400012203HD-ZIP family protein
PGSC0003DMP400013650HD-ZIP family protein
PGSC0003DMP400013651HD-ZIP family protein
PGSC0003DMP400014169HD-ZIP family protein
PGSC0003DMP400018388HD-ZIP family protein
PGSC0003DMP400019928HD-ZIP family protein
PGSC0003DMP400019929HD-ZIP family protein
PGSC0003DMP400020940HD-ZIP family protein
PGSC0003DMP400022005HD-ZIP family protein
PGSC0003DMP400022115HD-ZIP family protein
PGSC0003DMP400022480HD-ZIP family protein
PGSC0003DMP400023030HD-ZIP family protein
PGSC0003DMP400023457HD-ZIP family protein
PGSC0003DMP400025166HD-ZIP family protein
PGSC0003DMP400028207HD-ZIP family protein
PGSC0003DMP400028208HD-ZIP family protein
PGSC0003DMP400029101HD-ZIP family protein
PGSC0003DMP400029334HD-ZIP family protein
PGSC0003DMP400030811HD-ZIP family protein
PGSC0003DMP400030812HD-ZIP family protein
PGSC0003DMP400031061HD-ZIP family protein
PGSC0003DMP400031062HD-ZIP family protein
PGSC0003DMP400031076HD-ZIP family protein
PGSC0003DMP400032248HD-ZIP family protein
PGSC0003DMP400032249HD-ZIP family protein
PGSC0003DMP400033095HD-ZIP family protein
PGSC0003DMP400033998HD-ZIP family protein
PGSC0003DMP400036614HD-ZIP family protein
PGSC0003DMP400036615HD-ZIP family protein
PGSC0003DMP400036616HD-ZIP family protein
PGSC0003DMP400036873HD-ZIP family protein
PGSC0003DMP400037131HD-ZIP family protein
PGSC0003DMP400041027HD-ZIP family protein
PGSC0003DMP400041640HD-ZIP family protein
PGSC0003DMP400041641HD-ZIP family protein
PGSC0003DMP400041776HD-ZIP family protein
PGSC0003DMP400043964HD-ZIP family protein
PGSC0003DMP400044381HD-ZIP family protein
PGSC0003DMP400044383HD-ZIP family protein
PGSC0003DMP400044384HD-ZIP family protein
PGSC0003DMP400045076HD-ZIP family protein
PGSC0003DMP400045581HD-ZIP family protein
PGSC0003DMP400045953HD-ZIP family protein
PGSC0003DMP400045955HD-ZIP family protein
PGSC0003DMP400045957HD-ZIP family protein
PGSC0003DMP400046799HD-ZIP family protein
PGSC0003DMP400048281HD-ZIP family protein
PGSC0003DMP400048282HD-ZIP family protein
PGSC0003DMP400050744HD-ZIP family protein
PGSC0003DMP400050746HD-ZIP family protein
PGSC0003DMP400052108HD-ZIP family protein
PGSC0003DMP400053056HD-ZIP family protein
PGSC0003DMP400053718HD-ZIP family protein
PGSC0003DMP400053719HD-ZIP family protein
PGSC0003DMP400054811HD-ZIP family protein
PGSC0003DMP400055009HD-ZIP family protein
PGSC0003DMP400065799HD-ZIP family protein
PGSC0003DMP400068645HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401