PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Solanum pennellii
Species TF ID Description
Sopen01g034890.1MIKC_MADS family protein
Sopen01g034890.2MIKC_MADS family protein
Sopen01g037760.1MIKC_MADS family protein
Sopen01g037770.1MIKC_MADS family protein
Sopen01g048260.1MIKC_MADS family protein
Sopen02g015950.1MIKC_MADS family protein
Sopen02g020720.1MIKC_MADS family protein
Sopen02g020720.2MIKC_MADS family protein
Sopen02g029300.1MIKC_MADS family protein
Sopen02g033990.1MIKC_MADS family protein
Sopen02g033990.2MIKC_MADS family protein
Sopen02g034000.1MIKC_MADS family protein
Sopen02g036170.1MIKC_MADS family protein
Sopen02g036170.2MIKC_MADS family protein
Sopen03g002820.1MIKC_MADS family protein
Sopen03g029910.1MIKC_MADS family protein
Sopen03g033910.1MIKC_MADS family protein
Sopen03g033920.1MIKC_MADS family protein
Sopen04g001300.1MIKC_MADS family protein
Sopen04g001300.2MIKC_MADS family protein
Sopen04g008150.1MIKC_MADS family protein
Sopen04g031890.1MIKC_MADS family protein
Sopen04g031890.2MIKC_MADS family protein
Sopen04g034610.1MIKC_MADS family protein
Sopen05g006790.3MIKC_MADS family protein
Sopen05g011300.1MIKC_MADS family protein
Sopen06g020070.1MIKC_MADS family protein
Sopen06g023350.1MIKC_MADS family protein
Sopen06g026710.1MIKC_MADS family protein
Sopen07g029280.1MIKC_MADS family protein
Sopen08g021160.1MIKC_MADS family protein
Sopen08g028450.1MIKC_MADS family protein
Sopen10g006560.1MIKC_MADS family protein
Sopen10g030640.1MIKC_MADS family protein
Sopen11g001120.1MIKC_MADS family protein
Sopen11g005370.1MIKC_MADS family protein
Sopen11g012490.1MIKC_MADS family protein
Sopen11g014790.1MIKC_MADS family protein
Sopen12g018800.1MIKC_MADS family protein
Sopen12g029050.1MIKC_MADS family protein
Sopen12g029840.1MIKC_MADS family protein
Sopen12g029850.2MIKC_MADS family protein
Sopen12g030100.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513