PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Salvia miltiorrhiza
FAR1 Family
Species TF ID Description
SMil_00000072-RA_SalvFAR1 family protein
SMil_00001536-RA_SalvFAR1 family protein
SMil_00001965-RA_SalvFAR1 family protein
SMil_00002002-RA_SalvFAR1 family protein
SMil_00002447-RA_SalvFAR1 family protein
SMil_00002674-RA_SalvFAR1 family protein
SMil_00003473-RA_SalvFAR1 family protein
SMil_00004056-RA_SalvFAR1 family protein
SMil_00006394-RA_SalvFAR1 family protein
SMil_00007855-RA_SalvFAR1 family protein
SMil_00007899-RA_SalvFAR1 family protein
SMil_00008689-RA_SalvFAR1 family protein
SMil_00010479-RA_SalvFAR1 family protein
SMil_00010480-RA_SalvFAR1 family protein
SMil_00010958-RA_SalvFAR1 family protein
SMil_00011613-RA_SalvFAR1 family protein
SMil_00011916-RA_SalvFAR1 family protein
SMil_00012162-RA_SalvFAR1 family protein
SMil_00012347-RA_SalvFAR1 family protein
SMil_00012652-RA_SalvFAR1 family protein
SMil_00013210-RA_SalvFAR1 family protein
SMil_00013843-RA_SalvFAR1 family protein
SMil_00014153-RA_SalvFAR1 family protein
SMil_00014217-RA_SalvFAR1 family protein
SMil_00015146-RA_SalvFAR1 family protein
SMil_00016861-RA_SalvFAR1 family protein
SMil_00017098-RA_SalvFAR1 family protein
SMil_00017369-RA_SalvFAR1 family protein
SMil_00018430-RA_SalvFAR1 family protein
SMil_00019183-RA_SalvFAR1 family protein
SMil_00019582-RA_SalvFAR1 family protein
SMil_00019658-RA_SalvFAR1 family protein
SMil_00019815-RA_SalvFAR1 family protein
SMil_00020986-RA_SalvFAR1 family protein
SMil_00022442-RA_SalvFAR1 family protein
SMil_00023747-RA_SalvFAR1 family protein
SMil_00023932-RA_SalvFAR1 family protein
SMil_00024006-RA_SalvFAR1 family protein
SMil_00025013-RA_SalvFAR1 family protein
SMil_00025236-RA_SalvFAR1 family protein
SMil_00026639-RA_SalvFAR1 family protein
SMil_00029747-RA_SalvFAR1 family protein
SMil_00029947-RA_SalvFAR1 family protein
FAR1 Family Introduction

We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.

We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the "a" fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5'-TTCACGCGCC-3'. Mutating the core sequence "CACGCGC" of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, "CACGCGC" likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.

Lin R, Ding L, Casola C, Ripoll DR, Feschotte C, Wang H.
Transposase-derived transcription factors regulate light signaling in Arabidopsis.
Science, 2007. 318(5854): p. 1302-5.
PMID: 18033885