PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Sphagnum fallax
HD-ZIP Family
Species TF ID Description
Sphfalx0000s0161.1.pHD-ZIP family protein
Sphfalx0000s0161.2.pHD-ZIP family protein
Sphfalx0000s0161.3.pHD-ZIP family protein
Sphfalx0000s0161.4.pHD-ZIP family protein
Sphfalx0000s0668.1.pHD-ZIP family protein
Sphfalx0000s0670.1.pHD-ZIP family protein
Sphfalx0001s0077.1.pHD-ZIP family protein
Sphfalx0001s0083.1.pHD-ZIP family protein
Sphfalx0002s0297.1.pHD-ZIP family protein
Sphfalx0008s0122.1.pHD-ZIP family protein
Sphfalx0008s0251.1.pHD-ZIP family protein
Sphfalx0008s0253.1.pHD-ZIP family protein
Sphfalx0009s0011.1.pHD-ZIP family protein
Sphfalx0010s0147.1.pHD-ZIP family protein
Sphfalx0010s0187.1.pHD-ZIP family protein
Sphfalx0013s0106.1.pHD-ZIP family protein
Sphfalx0014s0045.1.pHD-ZIP family protein
Sphfalx0022s0100.1.pHD-ZIP family protein
Sphfalx0023s0043.1.pHD-ZIP family protein
Sphfalx0023s0046.1.pHD-ZIP family protein
Sphfalx0026s0055.1.pHD-ZIP family protein
Sphfalx0026s0103.1.pHD-ZIP family protein
Sphfalx0064s0126.1.pHD-ZIP family protein
Sphfalx0065s0086.1.pHD-ZIP family protein
Sphfalx0069s0076.1.pHD-ZIP family protein
Sphfalx0069s0076.2.pHD-ZIP family protein
Sphfalx0071s0093.1.pHD-ZIP family protein
Sphfalx0071s0095.1.pHD-ZIP family protein
Sphfalx0081s0063.1.pHD-ZIP family protein
Sphfalx0081s0063.2.pHD-ZIP family protein
Sphfalx0081s0063.3.pHD-ZIP family protein
Sphfalx0096s0076.1.pHD-ZIP family protein
Sphfalx0110s0070.1.pHD-ZIP family protein
Sphfalx0111s0027.1.pHD-ZIP family protein
Sphfalx0165s0024.1.pHD-ZIP family protein
Sphfalx0165s0024.2.pHD-ZIP family protein
Sphfalx0168s0005.1.pHD-ZIP family protein
Sphfalx0174s0009.1.pHD-ZIP family protein
Sphfalx0189s0018.1.pHD-ZIP family protein
Sphfalx0197s0030.1.pHD-ZIP family protein
Sphfalx0219s0008.1.pHD-ZIP family protein
Sphfalx0219s0009.1.pHD-ZIP family protein
Sphfalx0224s0023.1.pHD-ZIP family protein
Sphfalx0235s0010.1.pHD-ZIP family protein
Sphfalx0381s0004.1.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401