PlantRegMap/PlantTFDB v5.0
Plant Transcription
Factor Database
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Home TFext BLAST Prediction Download Help About Links PlantRegMap |
Species | TF ID | Description |
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Phvul.001G132000.1 | FAR1 family protein | |
Phvul.002G101200.1 | FAR1 family protein | |
Phvul.002G126900.1 | FAR1 family protein | |
Phvul.004G058200.1 | FAR1 family protein | |
Phvul.005G002900.1 | FAR1 family protein | |
Phvul.005G002900.2 | FAR1 family protein | |
Phvul.005G002900.3 | FAR1 family protein | |
Phvul.005G011700.1 | FAR1 family protein | |
Phvul.005G149300.1 | FAR1 family protein | |
Phvul.005G152800.1 | FAR1 family protein | |
Phvul.005G153200.1 | FAR1 family protein | |
Phvul.005G153200.2 | FAR1 family protein | |
Phvul.005G183900.1 | FAR1 family protein | |
Phvul.006G008300.1 | FAR1 family protein | |
Phvul.006G132500.1 | FAR1 family protein | |
Phvul.006G132600.1 | FAR1 family protein | |
Phvul.006G140500.1 | FAR1 family protein | |
Phvul.006G157300.1 | FAR1 family protein | |
Phvul.006G220900.1 | FAR1 family protein | |
Phvul.007G043200.1 | FAR1 family protein | |
Phvul.007G067000.1 | FAR1 family protein | |
Phvul.007G067000.2 | FAR1 family protein | |
Phvul.008G000100.1 | FAR1 family protein | |
Phvul.008G138000.1 | FAR1 family protein | |
Phvul.008G208300.1 | FAR1 family protein | |
Phvul.008G293000.1 | FAR1 family protein | |
Phvul.009G253800.1 | FAR1 family protein | |
Phvul.010G032600.1 | FAR1 family protein | |
Phvul.010G032600.2 | FAR1 family protein | |
Phvul.010G093300.1 | FAR1 family protein | |
Phvul.011G054000.1 | FAR1 family protein | |
Phvul.011G187200.1 | FAR1 family protein |
We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.
We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the "a" fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5'-TTCACGCGCC-3'. Mutating the core sequence "CACGCGC" of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, "CACGCGC" likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.
Lin R, Ding L, Casola C, Ripoll DR, Feschotte C, Wang H.
Transposase-derived transcription factors regulate light signaling in Arabidopsis.
Science, 2007. 318(5854): p. 1302-5.
PMID: 18033885