PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Picea sitchensis
bZIP Family
Species TF ID Description
Psi001104bZIP family protein
Psi002832bZIP family protein
Psi003642bZIP family protein
Psi003672bZIP family protein
Psi004822bZIP family protein
Psi004868bZIP family protein
Psi005375bZIP family protein
Psi005388bZIP family protein
Psi005439bZIP family protein
Psi005620bZIP family protein
Psi005795bZIP family protein
Psi006489bZIP family protein
Psi006518bZIP family protein
Psi006525bZIP family protein
Psi007367bZIP family protein
Psi008923bZIP family protein
Psi011567bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833