PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Oryza sativa subsp. japonica
bHLH Family
Species TF ID Description
LOC_Os01g01600.1bHLH family protein
LOC_Os01g01840.1bHLH family protein
LOC_Os01g01870.1bHLH family protein
LOC_Os01g02110.1bHLH family protein
LOC_Os01g06640.1bHLH family protein
LOC_Os01g06640.2bHLH family protein
LOC_Os01g09900.1bHLH family protein
LOC_Os01g09930.1bHLH family protein
LOC_Os01g09940.1bHLH family protein
LOC_Os01g09990.1bHLH family protein
LOC_Os01g09990.2bHLH family protein
LOC_Os01g11910.1bHLH family protein
LOC_Os01g13460.1bHLH family protein
LOC_Os01g18870.1bHLH family protein
LOC_Os01g33400.1bHLH family protein
LOC_Os01g38610.1bHLH family protein
LOC_Os01g39330.1bHLH family protein
LOC_Os01g39480.1bHLH family protein
LOC_Os01g39580.1bHLH family protein
LOC_Os01g50940.1bHLH family protein
LOC_Os01g51140.1bHLH family protein
LOC_Os01g51140.2bHLH family protein
LOC_Os01g56690.1bHLH family protein
LOC_Os01g57580.1bHLH family protein
LOC_Os01g61480.1bHLH family protein
LOC_Os01g64560.1bHLH family protein
LOC_Os01g64560.2bHLH family protein
LOC_Os01g67480.1bHLH family protein
LOC_Os01g68700.1bHLH family protein
LOC_Os01g68700.2bHLH family protein
LOC_Os01g70310.1bHLH family protein
LOC_Os01g70310.2bHLH family protein
LOC_Os01g72370.1bHLH family protein
LOC_Os01g72370.2bHLH family protein
LOC_Os01g72370.3bHLH family protein
LOC_Os02g02480.1bHLH family protein
LOC_Os02g02480.2bHLH family protein
LOC_Os02g02480.3bHLH family protein
LOC_Os02g02820.1bHLH family protein
LOC_Os02g12820.1bHLH family protein
LOC_Os02g13670.1bHLH family protein
LOC_Os02g15760.1bHLH family protein
LOC_Os02g23823.1bHLH family protein
LOC_Os02g23823.2bHLH family protein
LOC_Os02g23823.3bHLH family protein
LOC_Os02g34320.1bHLH family protein
LOC_Os02g34370.1bHLH family protein
LOC_Os02g35660.1bHLH family protein
LOC_Os02g39140.1bHLH family protein
LOC_Os02g46560.1bHLH family protein
LOC_Os02g47660.1bHLH family protein
LOC_Os02g48060.1bHLH family protein
LOC_Os02g49480.1bHLH family protein
LOC_Os02g51320.1bHLH family protein
LOC_Os02g52190.1bHLH family protein
LOC_Os02g55250.1bHLH family protein
LOC_Os02g56140.1bHLH family protein
LOC_Os03g03000.1bHLH family protein
LOC_Os03g04310.1bHLH family protein
LOC_Os03g04310.2bHLH family protein
LOC_Os03g07540.1bHLH family protein
LOC_Os03g08930.1bHLH family protein
LOC_Os03g10770.1bHLH family protein
LOC_Os03g12760.1bHLH family protein
LOC_Os03g12940.1bHLH family protein
LOC_Os03g12940.2bHLH family protein
LOC_Os03g15440.1bHLH family protein
LOC_Os03g17130.1bHLH family protein
LOC_Os03g26210.1bHLH family protein
LOC_Os03g26210.2bHLH family protein
LOC_Os03g26210.3bHLH family protein
LOC_Os03g27390.1bHLH family protein
LOC_Os03g27390.2bHLH family protein
LOC_Os03g42100.1bHLH family protein
LOC_Os03g43810.1bHLH family protein
LOC_Os03g46790.1bHLH family protein
LOC_Os03g46860.1bHLH family protein
LOC_Os03g51580.1bHLH family protein
LOC_Os03g51910.1bHLH family protein
LOC_Os03g53020.1bHLH family protein
LOC_Os03g55220.1bHLH family protein
LOC_Os03g55220.2bHLH family protein
LOC_Os03g55550.1bHLH family protein
LOC_Os03g56950.1bHLH family protein
LOC_Os03g56950.2bHLH family protein
LOC_Os03g56950.3bHLH family protein
LOC_Os03g56950.4bHLH family protein
LOC_Os03g56950.5bHLH family protein
LOC_Os03g56950.6bHLH family protein
LOC_Os03g56950.7bHLH family protein
LOC_Os03g58330.1bHLH family protein
LOC_Os03g58830.1bHLH family protein
LOC_Os03g59670.1bHLH family protein
LOC_Os04g23440.1bHLH family protein
LOC_Os04g23550.1bHLH family protein
LOC_Os04g23550.2bHLH family protein
LOC_Os04g28280.1bHLH family protein
LOC_Os04g31290.1bHLH family protein
LOC_Os04g35010.1bHLH family protein
LOC_Os04g41229.1bHLH family protein
LOC_Os04g41229.2bHLH family protein
LOC_Os04g47040.1bHLH family protein
LOC_Os04g47059.1bHLH family protein
LOC_Os04g47080.1bHLH family protein
LOC_Os04g50090.1bHLH family protein
LOC_Os04g51070.1bHLH family protein
LOC_Os04g52770.1bHLH family protein
LOC_Os04g53990.1bHLH family protein
LOC_Os04g54900.1bHLH family protein
LOC_Os05g01256.1bHLH family protein
LOC_Os05g01256.2bHLH family protein
LOC_Os05g04740.1bHLH family protein
LOC_Os05g04740.2bHLH family protein
LOC_Os05g06520.1bHLH family protein
LOC_Os05g07120.1bHLH family protein
LOC_Os05g07120.2bHLH family protein
LOC_Os05g11070.1bHLH family protein
LOC_Os05g38140.1bHLH family protein
LOC_Os05g42180.1bHLH family protein
LOC_Os05g46370.1bHLH family protein
LOC_Os05g50900.1bHLH family protein
LOC_Os05g51820.1bHLH family protein
LOC_Os06g06900.1bHLH family protein
LOC_Os06g08500.1bHLH family protein
LOC_Os06g09370.1bHLH family protein
LOC_Os06g09370.2bHLH family protein
LOC_Os06g09370.3bHLH family protein
LOC_Os06g10820.1bHLH family protein
LOC_Os06g12210.1bHLH family protein
LOC_Os06g16400.1bHLH family protein
LOC_Os06g16400.2bHLH family protein
LOC_Os06g30090.1bHLH family protein
LOC_Os06g33450.1bHLH family protein
LOC_Os06g33450.2bHLH family protein
LOC_Os06g37410.1bHLH family protein
LOC_Os06g50900.1bHLH family protein
LOC_Os07g05010.1bHLH family protein
LOC_Os07g05010.2bHLH family protein
LOC_Os07g05010.3bHLH family protein
LOC_Os07g09590.1bHLH family protein
LOC_Os07g35870.1bHLH family protein
LOC_Os07g35870.2bHLH family protein
LOC_Os07g36460.1bHLH family protein
LOC_Os07g39940.1bHLH family protein
LOC_Os07g43530.1bHLH family protein
LOC_Os07g43530.2bHLH family protein
LOC_Os08g01700.1bHLH family protein
LOC_Os08g04390.2bHLH family protein
LOC_Os08g08160.1bHLH family protein
LOC_Os08g33590.1bHLH family protein
LOC_Os08g36740.1bHLH family protein
LOC_Os08g37290.1bHLH family protein
LOC_Os08g37730.1bHLH family protein
LOC_Os08g38080.1bHLH family protein
LOC_Os08g38210.1bHLH family protein
LOC_Os08g38210.2bHLH family protein
LOC_Os08g38210.4bHLH family protein
LOC_Os08g38210.5bHLH family protein
LOC_Os08g39630.1bHLH family protein
LOC_Os08g41320.1bHLH family protein
LOC_Os08g42470.1bHLH family protein
LOC_Os08g43070.1bHLH family protein
LOC_Os09g24490.1bHLH family protein
LOC_Os09g25040.1bHLH family protein
LOC_Os09g28210.1bHLH family protein
LOC_Os09g28900.1bHLH family protein
LOC_Os09g29360.1bHLH family protein
LOC_Os09g29830.1bHLH family protein
LOC_Os09g29830.2bHLH family protein
LOC_Os09g29830.3bHLH family protein
LOC_Os09g29930.1bHLH family protein
LOC_Os09g29930.2bHLH family protein
LOC_Os09g29930.3bHLH family protein
LOC_Os09g31300.1bHLH family protein
LOC_Os09g31300.2bHLH family protein
LOC_Os09g32510.1bHLH family protein
LOC_Os09g32510.2bHLH family protein
LOC_Os09g32510.3bHLH family protein
LOC_Os09g32510.4bHLH family protein
LOC_Os09g32510.5bHLH family protein
LOC_Os09g33580.1bHLH family protein
LOC_Os09g33580.2bHLH family protein
LOC_Os09g34330.1bHLH family protein
LOC_Os10g01530.1bHLH family protein
LOC_Os10g23050.1bHLH family protein
LOC_Os10g26410.1bHLH family protein
LOC_Os10g26460.1bHLH family protein
LOC_Os10g39750.1bHLH family protein
LOC_Os10g40740.1bHLH family protein
LOC_Os10g42430.1bHLH family protein
LOC_Os11g06010.1bHLH family protein
LOC_Os11g15210.1bHLH family protein
LOC_Os11g25560.1bHLH family protein
LOC_Os11g32100.1bHLH family protein
LOC_Os11g38870.1bHLH family protein
LOC_Os11g38870.2bHLH family protein
LOC_Os11g39000.1bHLH family protein
LOC_Os11g39000.2bHLH family protein
LOC_Os11g41640.1bHLH family protein
LOC_Os12g31430.1bHLH family protein
LOC_Os12g32400.1bHLH family protein
LOC_Os12g39850.1bHLH family protein
LOC_Os12g40590.1bHLH family protein
LOC_Os12g40630.1bHLH family protein
LOC_Os12g40710.1bHLH family protein
LOC_Os12g40730.1bHLH family protein
LOC_Os12g41650.2bHLH family protein
LOC_Os12g41650.3bHLH family protein
LOC_Os12g41650.4bHLH family protein
LOC_Os12g41650.5bHLH family protein
LOC_Os12g43620.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250