PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Oryza sativa subsp. japonica
Species TF ID Description
LOC_Os01g10504.1MIKC_MADS family protein
LOC_Os01g10504.2MIKC_MADS family protein
LOC_Os01g10504.3MIKC_MADS family protein
LOC_Os01g52680.1MIKC_MADS family protein
LOC_Os01g66030.1MIKC_MADS family protein
LOC_Os01g66030.2MIKC_MADS family protein
LOC_Os01g66290.1MIKC_MADS family protein
LOC_Os01g66290.2MIKC_MADS family protein
LOC_Os02g01355.1MIKC_MADS family protein
LOC_Os02g01365.1MIKC_MADS family protein
LOC_Os02g07430.1MIKC_MADS family protein
LOC_Os02g36924.1MIKC_MADS family protein
LOC_Os02g45770.1MIKC_MADS family protein
LOC_Os02g49840.1MIKC_MADS family protein
LOC_Os02g49840.2MIKC_MADS family protein
LOC_Os02g49840.4MIKC_MADS family protein
LOC_Os02g52340.1MIKC_MADS family protein
LOC_Os03g08754.1MIKC_MADS family protein
LOC_Os03g08754.2MIKC_MADS family protein
LOC_Os03g11614.1MIKC_MADS family protein
LOC_Os03g54160.1MIKC_MADS family protein
LOC_Os03g54160.2MIKC_MADS family protein
LOC_Os03g54170.1MIKC_MADS family protein
LOC_Os04g23910.1MIKC_MADS family protein
LOC_Os04g49150.1MIKC_MADS family protein
LOC_Os04g52410.1MIKC_MADS family protein
LOC_Os04g52410.2MIKC_MADS family protein
LOC_Os05g11380.1MIKC_MADS family protein
LOC_Os05g11414.1MIKC_MADS family protein
LOC_Os05g34940.1MIKC_MADS family protein
LOC_Os05g34940.2MIKC_MADS family protein
LOC_Os05g34940.3MIKC_MADS family protein
LOC_Os06g01890.1MIKC_MADS family protein
LOC_Os06g06750.1MIKC_MADS family protein
LOC_Os06g11330.1MIKC_MADS family protein
LOC_Os06g45650.1MIKC_MADS family protein
LOC_Os06g49840.1MIKC_MADS family protein
LOC_Os06g49840.2MIKC_MADS family protein
LOC_Os07g01820.1MIKC_MADS family protein
LOC_Os07g01820.2MIKC_MADS family protein
LOC_Os07g01820.3MIKC_MADS family protein
LOC_Os07g01820.4MIKC_MADS family protein
LOC_Os07g01820.6MIKC_MADS family protein
LOC_Os07g41370.1MIKC_MADS family protein
LOC_Os08g02070.1MIKC_MADS family protein
LOC_Os08g33488.1MIKC_MADS family protein
LOC_Os08g41950.1MIKC_MADS family protein
LOC_Os08g41950.2MIKC_MADS family protein
LOC_Os08g41960.1MIKC_MADS family protein
LOC_Os09g32948.1MIKC_MADS family protein
LOC_Os10g39130.1MIKC_MADS family protein
LOC_Os10g39130.2MIKC_MADS family protein
LOC_Os12g10520.1MIKC_MADS family protein
LOC_Os12g10520.2MIKC_MADS family protein
LOC_Os12g10540.1MIKC_MADS family protein
LOC_Os12g10540.2MIKC_MADS family protein
LOC_Os12g10540.3MIKC_MADS family protein
LOC_Os12g10540.4MIKC_MADS family protein
LOC_Os12g10540.5MIKC_MADS family protein
LOC_Os12g31748.1MIKC_MADS family protein
LOC_Os12g31748.2MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513