PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana tomentosiformis
E2F/DP Family
Species TF ID Description
XP_009595017.1E2F/DP family protein
XP_009595018.1E2F/DP family protein
XP_009595019.1E2F/DP family protein
XP_009602094.1E2F/DP family protein
XP_009602095.1E2F/DP family protein
XP_009602096.1E2F/DP family protein
XP_009606865.1E2F/DP family protein
XP_009607525.1E2F/DP family protein
XP_009613530.1E2F/DP family protein
XP_009615454.1E2F/DP family protein
XP_009615455.1E2F/DP family protein
XP_009615456.1E2F/DP family protein
XP_009623945.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710