PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Nicotiana sylvestris
E2F/DP Family
Species TF ID Description
XP_009771455.1E2F/DP family protein
XP_009771456.1E2F/DP family protein
XP_009771457.1E2F/DP family protein
XP_009775269.1E2F/DP family protein
XP_009775271.1E2F/DP family protein
XP_009783024.1E2F/DP family protein
XP_009789426.1E2F/DP family protein
XP_009789428.1E2F/DP family protein
XP_009789429.1E2F/DP family protein
XP_009792084.1E2F/DP family protein
XP_009792091.1E2F/DP family protein
XP_009792094.1E2F/DP family protein
XP_009800726.1E2F/DP family protein
XP_009800733.1E2F/DP family protein
XP_009800740.1E2F/DP family protein
XP_009802122.1E2F/DP family protein
XP_009802123.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710