PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Helianthus annuus
bZIP Family
Species TF ID Description
Han000415bZIP family protein
Han000508bZIP family protein
Han001056bZIP family protein
Han001191bZIP family protein
Han001253bZIP family protein
Han001407bZIP family protein
Han001789bZIP family protein
Han002438bZIP family protein
Han002534bZIP family protein
Han002958bZIP family protein
Han003954bZIP family protein
Han004222bZIP family protein
Han004327bZIP family protein
Han004519bZIP family protein
Han004721bZIP family protein
Han007127bZIP family protein
Han007469bZIP family protein
Han007938bZIP family protein
Han008033bZIP family protein
Han008177bZIP family protein
Han008239bZIP family protein
Han008664bZIP family protein
Han008672bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833