PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Eutrema salsugineum
STAT Family
Species TF ID Description
Thhalv10006979mSTAT family protein
Thhalv10018251mSTAT family protein
STAT Familiy Introduction

The CudA and ECudA proteins share a 120 amino acid core of homology, and clustered point mutations introduced into two highly conserved motifs within the ECudA core region decrease its specific DNA binding in vitro. This region, the presumptive DNA-binding domain, is similar in sequence to domains in two Arabidopsis proteins and one Oryza protein. Significantly, these are the only proteins in the two plant species that contain an SH2 domain. Such a structure, with a DNA-binding domain located upstream of an SH2 domain, suggests that the plant proteins are orthologous to metazoan STATs. Consistent with this notion, the DNA sequence of the CudA half site, GAA, is identical to metazoan STAT half sites, although the relative positions of the two halves of the dyad are reversed. These results define a hitherto unrecognised class of transcription factors and suggest a model for the evolution of STATs and their DNA-binding sites.

Yamada Y, Wang HY, Fukuzawa M, Barton GJ, Williams JG.
A new family of transcription factors.
Development, 2008. 135(18): p. 3093-101.
PMID: 18701541