PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Eucalyptus camaldulensis
bHLH Family
Species TF ID Description
EcC000555.10bHLH family protein
EcC001023.20bHLH family protein
EcC003213.10bHLH family protein
EcC003469.40bHLH family protein
EcC003711.10bHLH family protein
EcC004408.10bHLH family protein
EcC005220.20bHLH family protein
EcC005899.20bHLH family protein
EcC007586.10bHLH family protein
EcC007630.30bHLH family protein
EcC007649.70bHLH family protein
EcC008702.20bHLH family protein
EcC009296.10bHLH family protein
EcC009465.40bHLH family protein
EcC010131.20bHLH family protein
EcC010696.40bHLH family protein
EcC013799.10bHLH family protein
EcC014643.10bHLH family protein
EcC015428.40bHLH family protein
EcC015995.40bHLH family protein
EcC016697.90bHLH family protein
EcC018017.10bHLH family protein
EcC018507.30bHLH family protein
EcC018675.20bHLH family protein
EcC021466.10bHLH family protein
EcC023190.70bHLH family protein
EcC023234.30bHLH family protein
EcC023354.10bHLH family protein
EcC023395.20bHLH family protein
EcC023963.10bHLH family protein
EcC027222.10bHLH family protein
EcC028212.10bHLH family protein
EcC029832.10bHLH family protein
EcC030907.10bHLH family protein
EcC031613.30bHLH family protein
EcC033255.10bHLH family protein
EcC033496.20bHLH family protein
EcC033786.20bHLH family protein
EcC034183.10bHLH family protein
EcC034723.20bHLH family protein
EcC034855.10bHLH family protein
EcC034960.10bHLH family protein
EcC035626.20bHLH family protein
EcC036168.10bHLH family protein
EcC037035.30bHLH family protein
EcC037164.10bHLH family protein
EcC037230.60bHLH family protein
EcC037330.10bHLH family protein
EcC038312.30bHLH family protein
EcC038428.10bHLH family protein
EcC038574.80bHLH family protein
EcC040478.10bHLH family protein
EcC040551.10bHLH family protein
EcC040884.10bHLH family protein
EcC041121.50bHLH family protein
EcC041431.20bHLH family protein
EcC041921.20bHLH family protein
EcC042303.30bHLH family protein
EcC042303.40bHLH family protein
EcC044038.60bHLH family protein
EcC044554.10bHLH family protein
EcC044966.20bHLH family protein
EcC045291.20bHLH family protein
EcC047434.60bHLH family protein
EcC047907.20bHLH family protein
EcC048006.30bHLH family protein
EcC048785.10bHLH family protein
EcC049087.20bHLH family protein
EcC050411.10bHLH family protein
EcC050517.40bHLH family protein
EcC050553.30bHLH family protein
EcC050567.10bHLH family protein
EcC050808.20bHLH family protein
EcC050846.20bHLH family protein
EcC051095.10bHLH family protein
EcC051101.10bHLH family protein
EcC051308.20bHLH family protein
EcC052023.20bHLH family protein
EcC052198.10bHLH family protein
EcC052511.10bHLH family protein
EcC052511.30bHLH family protein
EcC052533.60bHLH family protein
EcC052566.10bHLH family protein
EcC052705.10bHLH family protein
EcC052750.30bHLH family protein
EcC053464.10bHLH family protein
EcC053629.120bHLH family protein
EcC053790.70bHLH family protein
EcC053795.20bHLH family protein
EcC053800.60bHLH family protein
EcC054144.150bHLH family protein
EcC054247.10bHLH family protein
EcC054247.30bHLH family protein
EcC054295.10bHLH family protein
EcC054325.40bHLH family protein
EcC054609.50bHLH family protein
EcC054805.150bHLH family protein
EcC054812.160bHLH family protein
EcC054812.210bHLH family protein
EcC054812.220bHLH family protein
EcC054812.230bHLH family protein
EcC054819.200bHLH family protein
EcC054823.150bHLH family protein
EcC054864.90bHLH family protein
EcC054880.150bHLH family protein
EcC054899.60bHLH family protein
EcC054919.20bHLH family protein
EcC055126.40bHLH family protein
EcC055186.40bHLH family protein
EcC055200.40bHLH family protein
EcC055208.120bHLH family protein
EcC062834.10bHLH family protein
EcC063811.10bHLH family protein
EcC079473.10bHLH family protein
EcS527742.10bHLH family protein
EcS537378.10bHLH family protein
EcS539336.10bHLH family protein
EcS540524.10bHLH family protein
EcS567389.10bHLH family protein
EcS579793.10bHLH family protein
EcS722688.10bHLH family protein
EcS727258.10bHLH family protein
EcS730960.10bHLH family protein
EcS736265.10bHLH family protein
EcS741259.10bHLH family protein
EcS753124.10bHLH family protein
EcS754314.10bHLH family protein
EcS759259.10bHLH family protein
EcS762054.10bHLH family protein
EcS768161.10bHLH family protein
EcS769467.10bHLH family protein
EcS780960.10bHLH family protein
EcS782447.10bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250