PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Brassica rapa
MIKC_MADS Family
Species TF ID Description
XP_009102994.1MIKC_MADS family protein
XP_009102995.1MIKC_MADS family protein
XP_009103260.1MIKC_MADS family protein
XP_009104054.1MIKC_MADS family protein
XP_009104172.1MIKC_MADS family protein
XP_009104908.1MIKC_MADS family protein
XP_009105010.1MIKC_MADS family protein
XP_009105011.1MIKC_MADS family protein
XP_009105460.1MIKC_MADS family protein
XP_009105505.1MIKC_MADS family protein
XP_009105506.1MIKC_MADS family protein
XP_009105507.1MIKC_MADS family protein
XP_009105508.1MIKC_MADS family protein
XP_009105825.1MIKC_MADS family protein
XP_009106441.1MIKC_MADS family protein
XP_009107033.1MIKC_MADS family protein
XP_009107038.1MIKC_MADS family protein
XP_009107040.1MIKC_MADS family protein
XP_009107045.1MIKC_MADS family protein
XP_009107050.1MIKC_MADS family protein
XP_009107059.1MIKC_MADS family protein
XP_009107066.1MIKC_MADS family protein
XP_009107076.1MIKC_MADS family protein
XP_009107084.1MIKC_MADS family protein
XP_009108594.1MIKC_MADS family protein
XP_009108595.1MIKC_MADS family protein
XP_009109211.1MIKC_MADS family protein
XP_009109212.1MIKC_MADS family protein
XP_009109406.1MIKC_MADS family protein
XP_009109825.1MIKC_MADS family protein
XP_009109826.1MIKC_MADS family protein
XP_009109914.1MIKC_MADS family protein
XP_009109916.1MIKC_MADS family protein
XP_009110147.1MIKC_MADS family protein
XP_009111804.1MIKC_MADS family protein
XP_009111964.1MIKC_MADS family protein
XP_009111965.1MIKC_MADS family protein
XP_009112008.1MIKC_MADS family protein
XP_009112514.1MIKC_MADS family protein
XP_009113581.1MIKC_MADS family protein
XP_009113582.1MIKC_MADS family protein
XP_009113583.1MIKC_MADS family protein
XP_009113584.1MIKC_MADS family protein
XP_009113782.1MIKC_MADS family protein
XP_009113783.1MIKC_MADS family protein
XP_009114655.1MIKC_MADS family protein
XP_009114656.1MIKC_MADS family protein
XP_009115015.1MIKC_MADS family protein
XP_009115272.1MIKC_MADS family protein
XP_009116122.1MIKC_MADS family protein
XP_009116442.1MIKC_MADS family protein
XP_009116562.1MIKC_MADS family protein
XP_009117344.1MIKC_MADS family protein
XP_009117898.1MIKC_MADS family protein
XP_009120826.1MIKC_MADS family protein
XP_009121545.1MIKC_MADS family protein
XP_009121726.1MIKC_MADS family protein
XP_009121728.1MIKC_MADS family protein
XP_009122081.1MIKC_MADS family protein
XP_009122082.1MIKC_MADS family protein
XP_009122083.1MIKC_MADS family protein
XP_009122084.1MIKC_MADS family protein
XP_009123192.1MIKC_MADS family protein
XP_009123193.1MIKC_MADS family protein
XP_009125323.1MIKC_MADS family protein
XP_009125324.1MIKC_MADS family protein
XP_009126431.1MIKC_MADS family protein
XP_009126432.1MIKC_MADS family protein
XP_009127703.1MIKC_MADS family protein
XP_009127862.1MIKC_MADS family protein
XP_009129078.1MIKC_MADS family protein
XP_009129675.1MIKC_MADS family protein
XP_009130118.1MIKC_MADS family protein
XP_009130119.1MIKC_MADS family protein
XP_009130120.1MIKC_MADS family protein
XP_009130138.1MIKC_MADS family protein
XP_009130170.1MIKC_MADS family protein
XP_009130198.1MIKC_MADS family protein
XP_009130486.1MIKC_MADS family protein
XP_009130487.1MIKC_MADS family protein
XP_009130488.1MIKC_MADS family protein
XP_009130489.1MIKC_MADS family protein
XP_009131145.1MIKC_MADS family protein
XP_009131359.1MIKC_MADS family protein
XP_009131360.1MIKC_MADS family protein
XP_009131500.1MIKC_MADS family protein
XP_009131786.1MIKC_MADS family protein
XP_009131941.1MIKC_MADS family protein
XP_009132356.1MIKC_MADS family protein
XP_009132365.1MIKC_MADS family protein
XP_009132372.1MIKC_MADS family protein
XP_009132380.1MIKC_MADS family protein
XP_009132388.1MIKC_MADS family protein
XP_009132395.1MIKC_MADS family protein
XP_009132580.1MIKC_MADS family protein
XP_009132581.1MIKC_MADS family protein
XP_009132582.1MIKC_MADS family protein
XP_009132583.1MIKC_MADS family protein
XP_009132584.1MIKC_MADS family protein
XP_009132707.1MIKC_MADS family protein
XP_009133732.1MIKC_MADS family protein
XP_009133733.1MIKC_MADS family protein
XP_009133734.1MIKC_MADS family protein
XP_009133735.1MIKC_MADS family protein
XP_009133736.1MIKC_MADS family protein
XP_009133737.1MIKC_MADS family protein
XP_009134170.1MIKC_MADS family protein
XP_009134171.1MIKC_MADS family protein
XP_009134172.1MIKC_MADS family protein
XP_009134173.1MIKC_MADS family protein
XP_009134174.1MIKC_MADS family protein
XP_009136371.1MIKC_MADS family protein
XP_009136372.1MIKC_MADS family protein
XP_009136373.1MIKC_MADS family protein
XP_009136412.1MIKC_MADS family protein
XP_009136477.1MIKC_MADS family protein
XP_009136478.1MIKC_MADS family protein
XP_009136479.1MIKC_MADS family protein
XP_009136496.1MIKC_MADS family protein
XP_009136975.1MIKC_MADS family protein
XP_009136976.1MIKC_MADS family protein
XP_009136977.1MIKC_MADS family protein
XP_009136978.1MIKC_MADS family protein
XP_009136979.1MIKC_MADS family protein
XP_009137303.1MIKC_MADS family protein
XP_009137304.1MIKC_MADS family protein
XP_009137453.1MIKC_MADS family protein
XP_009137454.1MIKC_MADS family protein
XP_009137455.1MIKC_MADS family protein
XP_009138166.1MIKC_MADS family protein
XP_009138171.1MIKC_MADS family protein
XP_009138179.1MIKC_MADS family protein
XP_009138187.1MIKC_MADS family protein
XP_009138194.1MIKC_MADS family protein
XP_009138200.1MIKC_MADS family protein
XP_009138207.1MIKC_MADS family protein
XP_009138271.1MIKC_MADS family protein
XP_009138791.1MIKC_MADS family protein
XP_009138792.1MIKC_MADS family protein
XP_009138793.1MIKC_MADS family protein
XP_009138935.1MIKC_MADS family protein
XP_009139036.1MIKC_MADS family protein
XP_009139222.1MIKC_MADS family protein
XP_009139246.1MIKC_MADS family protein
XP_009140365.1MIKC_MADS family protein
XP_009140371.1MIKC_MADS family protein
XP_009141444.1MIKC_MADS family protein
XP_009141450.1MIKC_MADS family protein
XP_009141455.1MIKC_MADS family protein
XP_009141461.1MIKC_MADS family protein
XP_009142352.1MIKC_MADS family protein
XP_009142353.1MIKC_MADS family protein
XP_009142866.1MIKC_MADS family protein
XP_009142867.1MIKC_MADS family protein
XP_009142869.1MIKC_MADS family protein
XP_009142870.1MIKC_MADS family protein
XP_009142871.1MIKC_MADS family protein
XP_009142872.1MIKC_MADS family protein
XP_009143157.1MIKC_MADS family protein
XP_009143158.1MIKC_MADS family protein
XP_009147359.1MIKC_MADS family protein
XP_009147629.1MIKC_MADS family protein
XP_009150582.1MIKC_MADS family protein
XP_009150583.1MIKC_MADS family protein
XP_009150584.1MIKC_MADS family protein
XP_009150585.1MIKC_MADS family protein
XP_009151758.1MIKC_MADS family protein
XP_009152152.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513