PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Brassica napus
RAV Family
Species TF ID Description
GSBRNA2T00003011001RAV family protein
GSBRNA2T00021143001RAV family protein
GSBRNA2T00021160001RAV family protein
GSBRNA2T00021173001RAV family protein
GSBRNA2T00023485001RAV family protein
GSBRNA2T00026623001RAV family protein
GSBRNA2T00027433001RAV family protein
GSBRNA2T00029169001RAV family protein
GSBRNA2T00033750001RAV family protein
GSBRNA2T00043338001RAV family protein
GSBRNA2T00043362001RAV family protein
GSBRNA2T00048280001RAV family protein
GSBRNA2T00058893001RAV family protein
GSBRNA2T00059936001RAV family protein
GSBRNA2T00063329001RAV family protein
GSBRNA2T00063330001RAV family protein
GSBRNA2T00063364001RAV family protein
GSBRNA2T00072242001RAV family protein
GSBRNA2T00077984001RAV family protein
GSBRNA2T00082795001RAV family protein
GSBRNA2T00085787001RAV family protein
GSBRNA2T00090567001RAV family protein
GSBRNA2T00105354001RAV family protein
GSBRNA2T00108406001RAV family protein
GSBRNA2T00135275001RAV family protein
GSBRNA2T00139176001RAV family protein
GSBRNA2T00142419001RAV family protein
RAV Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

Recently, the involvement of members of the RAV family in ethylene response and in brassinosteroid response was reported.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444

The third class of AP2/EREBP-like proteins that have been shown to bind DNA consists of Arabidopsis RAV1 and RAV2. RAV1 and RAV2 are highly related proteins that contain two DNA binding motifs: a single AP2 repeat and a B3-like domain. RAV1 binds to a bipartite recognition sequence with the AP2 repeat binding to a CAACA motif and the B3 domain binding to a CACCTG sequence. Although either domain can bind DNA on its own, a much higher DNA binding affinity is achieved when both domains are present. The AP2 domains of RAV1 and RAV2 are more diverged from those of the EREBP-like proteins and may be considered a third subfamily of the AP2/EREBP family.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102