PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Arabidopsis thaliana
WOX Family
Species TF ID Description
AT1G20700.1WUSCHEL related homeobox 14
AT1G20710.1WUSCHEL related homeobox 10
AT1G46480.1WUSCHEL related homeobox 4
AT2G01500.1WOX family protein
AT2G17950.1WOX family protein
AT2G28610.1WOX family protein
AT3G03660.1WUSCHEL related homeobox 11
AT3G03660.2WUSCHEL related homeobox 11
AT3G11260.1WUSCHEL related homeobox 5
AT3G18010.1WUSCHEL related homeobox 1
AT4G35550.1WUSCHEL related homeobox 13
AT5G05770.1WUSCHEL related homeobox 7
AT5G17810.1WUSCHEL related homeobox 12
AT5G17810.2WUSCHEL related homeobox 12
AT5G45980.1WUSCHEL related homeobox 8
AT5G46010.1WOX family protein
AT5G59340.1WUSCHEL related homeobox 2
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401

The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590