PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Amaranthus hypochondriacus
HD-ZIP Family
Species TF ID Description
AHYPO_000355-RAHD-ZIP family protein
AHYPO_000642-RAHD-ZIP family protein
AHYPO_001551-RAHD-ZIP family protein
AHYPO_001855-RAHD-ZIP family protein
AHYPO_002107-RAHD-ZIP family protein
AHYPO_002305-RAHD-ZIP family protein
AHYPO_002340-RAHD-ZIP family protein
AHYPO_007538-RAHD-ZIP family protein
AHYPO_009096-RAHD-ZIP family protein
AHYPO_009623-RAHD-ZIP family protein
AHYPO_010116-RAHD-ZIP family protein
AHYPO_010424-RAHD-ZIP family protein
AHYPO_011483-RAHD-ZIP family protein
AHYPO_011618-RAHD-ZIP family protein
AHYPO_012165-RAHD-ZIP family protein
AHYPO_012563-RAHD-ZIP family protein
AHYPO_012630-RAHD-ZIP family protein
AHYPO_013919-RAHD-ZIP family protein
AHYPO_015165-RAHD-ZIP family protein
AHYPO_015451-RAHD-ZIP family protein
AHYPO_016153-RAHD-ZIP family protein
AHYPO_018754-RAHD-ZIP family protein
AHYPO_019152-RAHD-ZIP family protein
AHYPO_019255-RAHD-ZIP family protein
AHYPO_019492-RAHD-ZIP family protein
AHYPO_019704-RAHD-ZIP family protein
AHYPO_021301-RAHD-ZIP family protein
AHYPO_021629-RAHD-ZIP family protein
AHYPO_021633-RAHD-ZIP family protein
AHYPO_021978-RAHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401