PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Arachis duranensis
Species TF ID Description
Aradu.0Q5NSMIKC_MADS family protein
Aradu.22X1PMIKC_MADS family protein
Aradu.32WCYMIKC_MADS family protein
Aradu.3C80GMIKC_MADS family protein
Aradu.44JDKMIKC_MADS family protein
Aradu.66DGFMIKC_MADS family protein
Aradu.91WCTMIKC_MADS family protein
Aradu.92XHBMIKC_MADS family protein
Aradu.95Z4FMIKC_MADS family protein
Aradu.9FL9LMIKC_MADS family protein
Aradu.B59SFMIKC_MADS family protein
Aradu.C0RFPMIKC_MADS family protein
Aradu.C3MS1MIKC_MADS family protein
Aradu.EGK1MMIKC_MADS family protein
Aradu.G8P6YMIKC_MADS family protein
Aradu.GUV6VMIKC_MADS family protein
Aradu.H2R03MIKC_MADS family protein
Aradu.KAZ0GMIKC_MADS family protein
Aradu.KWJ2KMIKC_MADS family protein
Aradu.MYH00MIKC_MADS family protein
Aradu.N9KWNMIKC_MADS family protein
Aradu.NS10GMIKC_MADS family protein
Aradu.NVB9VMIKC_MADS family protein
Aradu.P04DIMIKC_MADS family protein
Aradu.Q6KDHMIKC_MADS family protein
Aradu.QZ653MIKC_MADS family protein
Aradu.S1UIQMIKC_MADS family protein
Aradu.S4CJ2MIKC_MADS family protein
Aradu.TB6GCMIKC_MADS family protein
Aradu.TY4I3MIKC_MADS family protein
Aradu.UG0RVMIKC_MADS family protein
Aradu.UJ9WAMIKC_MADS family protein
Aradu.X0I6LMIKC_MADS family protein
Aradu.X280AMIKC_MADS family protein
Aradu.Y02KHMIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513