PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Artemisia annua
WRKY Family
Species TF ID Description
Aan000903WRKY family protein
Aan002068WRKY family protein
Aan002662WRKY family protein
Aan002750WRKY family protein
Aan002969WRKY family protein
Aan003018WRKY family protein
Aan005344WRKY family protein
Aan005642WRKY family protein
Aan006074WRKY family protein
Aan006281WRKY family protein
Aan007738WRKY family protein
Aan009151WRKY family protein
Aan010476WRKY family protein
Aan013098WRKY family protein
Aan014023WRKY family protein
Aan014220WRKY family protein
Aan015105WRKY family protein
Aan015477WRKY family protein
Aan015725WRKY family protein
Aan015851WRKY family protein
Aan016550WRKY family protein
Aan016565WRKY family protein
Aan016643WRKY family protein
Aan016676WRKY family protein
Aan016800WRKY family protein
Aan017296WRKY family protein
Aan018929WRKY family protein
Aan018999WRKY family protein
Aan019013WRKY family protein
Aan019796WRKY family protein
Aan019797WRKY family protein
Aan020089WRKY family protein
Aan020136WRKY family protein
Aan020263WRKY family protein
Aan020729WRKY family protein
Aan021126WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701